This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5\%) HSE patients died and 48 (89\%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53\%) of whom received 10 mg/kg t.i.d. and 22 (47\%) received 15 mg/kg t.i.d. The mortality rate was low despite 49\% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.
%0 Journal Article
%1 Stahl2012
%A Stahl, J. P.
%A Mailles, A.
%A De Broucker, T.
%D 2012
%J Epidemiol Infect
%K hsv encephalitis
%N 2
%P 372--381
%R 10.1017/S0950268811000483
%T Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France.
%U http://dx.doi.org/10.1017/S0950268811000483
%V 140
%X This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5\%) HSE patients died and 48 (89\%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53\%) of whom received 10 mg/kg t.i.d. and 22 (47\%) received 15 mg/kg t.i.d. The mortality rate was low despite 49\% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.
@article{Stahl2012,
abstract = {This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5\%) HSE patients died and 48 (89\%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53\%) of whom received 10 mg/kg t.i.d. and 22 (47\%) received 15 mg/kg t.i.d. The mortality rate was low despite 49\% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.},
added-at = {2012-05-16T00:37:49.000+0200},
author = {Stahl, J. P. and Mailles, A. and {De Broucker}, T.},
biburl = {https://www.bibsonomy.org/bibtex/2f830a4fa3e5d0983645ead2218e04281/aorchid},
doi = {10.1017/S0950268811000483},
file = {:ID_General/Virus_Non-HIV/EpidemiolInfect.140.372.pdf:PDF},
groups = {public},
institution = {Infectious Diseases Unit, University Grenoble 1, Grenoble, France.},
interhash = {11fc147dee65ddeb473a3a2cd5bb54f5},
intrahash = {f830a4fa3e5d0983645ead2218e04281},
journal = {Epidemiol Infect},
keywords = {hsv encephalitis},
language = {eng},
medline-pst = {ppublish},
month = Feb,
number = 2,
pages = {372--381},
pii = {S0950268811000483},
pmid = {21470440},
timestamp = {2012-05-16T00:37:49.000+0200},
title = {Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France.},
url = {http://dx.doi.org/10.1017/S0950268811000483},
username = {aorchid},
volume = 140,
year = 2012
}