%0 Journal Article %1 cheng20may2019study %A Cheng, Xu %A Liu, Baosheng %A Zhang, Hongcai %D 20 May, 2019 %J Advances in Biochemistry and Biotechnology %K Binding Oral Pepsin Spectrometry Trypsin. drugs rate %N 02 %P 8 %T Study on the Binding Rate of Oral Drugs with Pepsin and Trypsin %U https://www.gavinpublishers.com/articles/Review-Article/Advances-in-Biochemistry-and-Biotechnology-ISSN-2574-7258/study-on-the-binding-rate-of-oral-drugs-with-pepsin-and-trypsin %V 7 %X In order to find a research method to quickly predict the effects of oral drugs on the human digestive system, in this paper, a mathematical model of the binding rate of pepsin and trypsin was established by using the binding constant Ka and the number of binding sites n (n=1) of digestive protease (pepsin, trypsin) and common oral drugs reported under the simulative human physiological conditions. Using this model, the drug binding rate and protein binding rate of different drugs with pepsin and trypsin were calculated, which could predict the influence of drugs on human digestive function. The results showed that the effect of the drug speculated by the method on the digestive function of the human body was basically consistent with the side effects of the drug described in the drug manual. The method is simple and rapid, and provides an auxiliary means for studying the influence of oral drugs on human digestive function. This method has found a new way of thinking about the effect of oral drugs on human digestive function.

@article{cheng20may2019study, abstract = {In order to find a research method to quickly predict the effects of oral drugs on the human digestive system, in this paper, a mathematical model of the binding rate of pepsin and trypsin was established by using the binding constant Ka and the number of binding sites n (n=1) of digestive protease (pepsin, trypsin) and common oral drugs reported under the simulative human physiological conditions. Using this model, the drug binding rate and protein binding rate of different drugs with pepsin and trypsin were calculated, which could predict the influence of drugs on human digestive function. The results showed that the effect of the drug speculated by the method on the digestive function of the human body was basically consistent with the side effects of the drug described in the drug manual. The method is simple and rapid, and provides an auxiliary means for studying the influence of oral drugs on human digestive function. This method has found a new way of thinking about the effect of oral drugs on human digestive function.}, added-at = {2019-07-04T11:52:34.000+0200}, author = {Cheng, Xu and Liu, Baosheng and Zhang, Hongcai}, biburl = {https://www.bibsonomy.org/bibtex/2fc5786608d37d6afe61e338f6455fa4c/alyssacarter}, interhash = {ae62c551aea70d62cfa71024e14467a2}, intrahash = {fc5786608d37d6afe61e338f6455fa4c}, issn = {ISSN:2574-7258}, journal = {Advances in Biochemistry and Biotechnology}, keywords = {Binding Oral Pepsin Spectrometry Trypsin. drugs rate}, language = {English}, month = {20 May}, number = 02, pages = 8, timestamp = {2019-07-04T11:52:34.000+0200}, title = {Study on the Binding Rate of Oral Drugs with Pepsin and Trypsin}, url = {https://www.gavinpublishers.com/articles/Review-Article/Advances-in-Biochemistry-and-Biotechnology-ISSN-2574-7258/study-on-the-binding-rate-of-oral-drugs-with-pepsin-and-trypsin}, volume = 7, year = {20 May, 2019} }