%0 Journal Article %1 RN65 %A Garcia-Beltran, O. %A Mena, N. %A Berrios, T.A. %A Castro, E.A. %A Cassels, B.K. %A Nunez, M.T. %A Aliaga, M.E. %D 2012 %I 2012 Elsevier Ltd. %J Tetrahedron Letters %K biothiols, chemodosimeter, coumarin derivatives, design, dqcauchile fluorescent fluorescent, hg(ii) hg2+ hg2+-selectivity, ions, molecules, probe, recognition, rhodamine-based sensor %N 48 %P 6598-6601 %R 10.1016/j.tetlet.2012.09.111 %T A Selective Fluorescent Probe for the Detection of Mercury (Ii) in Aqueous Media and Its Applications in Living Cells %U /brokenurl#<Go to ISI>://WOS:000311021600030 %V 53 %X In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg2+) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg2+. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells.

@article{RN65, abstract = {In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg2+) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg2+. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Garcia-Beltran, O. and Mena, N. and Berrios, T.A. and Castro, E.A. and Cassels, B.K. and Nunez, M.T. and Aliaga, M.E.}, biburl = {https://www.bibsonomy.org/bibtex/2ff4e42d2f3b25dd2ede9e77c77e2cf5c/dqcauchile}, doi = {10.1016/j.tetlet.2012.09.111}, interhash = {ac207aa9623272d3f21605446176a30e}, intrahash = {ff4e42d2f3b25dd2ede9e77c77e2cf5c}, issn = {0040-4039}, journal = {Tetrahedron Letters}, keywords = {biothiols, chemodosimeter, coumarin derivatives, design, dqcauchile fluorescent fluorescent, hg(ii) hg2+ hg2+-selectivity, ions, molecules, probe, recognition, rhodamine-based sensor}, number = 48, pages = {6598-6601}, publisher = {2012 Elsevier Ltd.}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {A Selective Fluorescent Probe for the Detection of Mercury (Ii) in Aqueous Media and Its Applications in Living Cells}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000311021600030}, volume = 53, year = 2012 }