Article,

Robust linear mixed models with skew-normal independent distributions from a Bayesian perspective

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Journal of Statistical Planning and Inference, 139 (12): 4098--4110 (2009)
DOI: 10.1016/j.jspi.2009.05.040,

Abstract

Linear mixed models were developed to handle clustered data and have been a topic of increasing interest in statistics for the past 50 years. Generally, the normality (or symmetry) of the random effects is a common assumption in linear mixed models but it may, sometimes, be unrealistic, obscuring important features of among-subjects variation. In this article, we utilize skew-normal/independent distributions as a tool for robust modeling of linear mixed models under a Bayesian paradigm. The skew-normal/independent distributions is an attractive class of asymmetric heavy-tailed distributions that includes the skew-normal distribution, skew-t, skew-slash and the skew-contaminated normal distributions as special cases, providing an appealing robust alternative to the routine use of symmetric distributions in this type of models. The methods developed are illustrated using a real data set from Framingham cholesterol study. Keywords Gibbs algorithms; Linear mixed models; MCMC; Metropolis–Hastings; Skew-normal/independent distribution

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