%0 Journal Article %1 WOS:000335107300019 %A Pereira, Gabriela Garrastazu %A Santos-Oliveira, Ralph %A Albernaz, Martha S %A Canema, Daniel %A Weismueller, Gilberto %A Barros, Eduardo Bede %A Magalhaes, Luciana %A Lima-Ribeiro, Maria Helena Madruga %A Pohlmann, Adriana Raffin %A Guterres, Silvia S %C RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS %D 2014 %I ELSEVIER %J EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS %K Atomic In Skin; Technetium-99m; cicatrization} force microscopy; vivo {Burn; %N 2 %P 292-300 %R 10.1016/j.ejpb.2013.10.011 %T Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment %V 86 %X The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. (c) 2013 Elsevier B.V. All rights reserved.

@article{WOS:000335107300019, abstract = {The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. (c) 2013 Elsevier B.V. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS}, author = {Pereira, Gabriela Garrastazu and Santos-Oliveira, Ralph and Albernaz, Martha S and Canema, Daniel and Weismueller, Gilberto and Barros, Eduardo Bede and Magalhaes, Luciana and Lima-Ribeiro, Maria Helena Madruga and Pohlmann, Adriana Raffin and Guterres, Silvia S}, biburl = {https://www.bibsonomy.org/bibtex/27b690eaca4f30e4710d3c127a928cd98/ppgfis_ufc_br}, doi = {10.1016/j.ejpb.2013.10.011}, interhash = {320e7476835052233ff65fc047eb333e}, intrahash = {7b690eaca4f30e4710d3c127a928cd98}, issn = {0939-6411}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}, keywords = {Atomic In Skin; Technetium-99m; cicatrization} force microscopy; vivo {Burn;}, number = 2, pages = {292-300}, publisher = {ELSEVIER}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment}, tppubtype = {article}, volume = 86, year = 2014 }