Abstract
The use of drug-loaded nanoparticles and microparticles has been
increasing, especially for cosmetic and drug delivery purposes. In this
work, a new microparticle formulation was developed for use in the
healing process of skin burns in a composition of Aloe vera/vitamin
E/chitosan. In order to observe the morphological properties, Raman and
atomic force microscopy evaluation were performed. The biodistribution
studies were analyzed by using a nuclear methodology, labeling the
microparticles with Technetium-99m and in vivo test was procedure to
analyzed the cicatrization process. The results of AFM analysis show the
formation and the adherence property of the microparticles. Raman
analyses show the distribution of each component in the microparticle.
The nuclear method used shows that the biodistribution of the
microparticles remained in the skin. The in vivo cicatrization test
showed that the poloxamer gel containing the microparticles make a
better cicatrization in relation to the other formulations tested. (c)
2013 Elsevier B.V. All rights reserved.
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