%0 Journal Article %1 Sheth2016Manipulating %A Sheth, Ravi U. %A Cabral, Vitor %A Chen, Sway P. %A Wang, Harris H. %D 2016 %I Elsevier %J Trends in Genetics %K communities %N 4 %P 189--200 %R 10.1016/j.tig.2016.01.005 %T Manipulating Bacterial Communities by <em>in situ</em> Microbiome Engineering %U http://dx.doi.org/10.1016/j.tig.2016.01.005 %V 32 %X Microbial communities inhabit our entire planet and have a crucial role in biogeochemical processes, agriculture, biotechnology, and human health. Here, we argue that ?in situ microbiome engineering? represents a new paradigm of community-scale genetic and microbial engineering. We discuss contemporary applications of this approach to directly add, remove, or modify specific sets of functions and alter community-level properties in terrestrial, aquatic, and host-associated microbial communities. Specifically, we highlight emerging in situ genome engineering approaches as tractable techniques to manipulate microbial communities with high specificity and efficacy. Finally, we describe opportunities for technological innovation and ways to bridge existing knowledge gaps to accelerate the development of in situ approaches for microbiome manipulations.

@article{Sheth2016Manipulating, abstract = {Microbial communities inhabit our entire planet and have a crucial role in biogeochemical processes, agriculture, biotechnology, and human health. Here, we argue that ?in situ microbiome engineering? represents a new paradigm of community-scale genetic and microbial engineering. We discuss contemporary applications of this approach to directly add, remove, or modify specific sets of functions and alter community-level properties in terrestrial, aquatic, and host-associated microbial communities. Specifically, we highlight emerging in situ genome engineering approaches as tractable techniques to manipulate microbial communities with high specificity and efficacy. Finally, we describe opportunities for technological innovation and ways to bridge existing knowledge gaps to accelerate the development of in situ approaches for microbiome manipulations.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Sheth, Ravi U. and Cabral, Vitor and Chen, Sway P. and Wang, Harris H.}, biburl = {https://www.bibsonomy.org/bibtex/2cb8883f125b436db235aeb61054d431b/karthikraman}, citeulike-article-id = {13984623}, citeulike-linkout-0 = {http://www.cell.com/genetics/abstract/S0168-9525(16)00015-9}, citeulike-linkout-1 = {http://dx.doi.org/10.1016/j.tig.2016.01.005}, day = 19, doi = {10.1016/j.tig.2016.01.005}, interhash = {3210749c56a6d63a5718ee438608812f}, intrahash = {cb8883f125b436db235aeb61054d431b}, issn = {01689525}, journal = {Trends in Genetics}, keywords = {communities}, month = apr, number = 4, pages = {189--200}, posted-at = {2016-04-19 17:10:45}, priority = {2}, publisher = {Elsevier}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Manipulating Bacterial Communities by <em>in situ</em> Microbiome Engineering}, url = {http://dx.doi.org/10.1016/j.tig.2016.01.005}, volume = 32, year = 2016 }