%0 Journal Article %1 Jung2019 %A Jung, Alexander %A Staat, Manfred %D 2019 %J GAMM-Mitteilungen %K cardiomyocytes,multi-scale computer coupling,fibroblasts,hiPSC-derived electromechanical model,pharmacology %N 4 %P e201900002 %R 10.1002/gamm.201900002 %T Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue %U https://onlinelibrary.wiley.com/doi/full/10.1002/gamm.201900002 http://doi.wiley.com/10.1002/gamm.201900002 %V 42 %X Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a promising in vitro model for human native cardiomyocytes. Cultivated tissue samples beat autonomously and can be used for basic and pharmacological research. For mechanical measurements of these tissue samples, the CellDrum technology has been developed. Measurements are extended by simulations with a multi-scale electromechanically coupled FEM based model. This model can be parameterized and validated experimentally. The paper describes the model, its workflow, and preliminary simulations to study the effect of fibroblasts and a selected cardiac drug on the electromechanics of hiPSC-CMs.

@article{Jung2019, abstract = {Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a promising in vitro model for human native cardiomyocytes. Cultivated tissue samples beat autonomously and can be used for basic and pharmacological research. For mechanical measurements of these tissue samples, the CellDrum technology has been developed. Measurements are extended by simulations with a multi-scale electromechanically coupled FEM based model. This model can be parameterized and validated experimentally. The paper describes the model, its workflow, and preliminary simulations to study the effect of fibroblasts and a selected cardiac drug on the electromechanics of hiPSC-CMs.}, added-at = {2019-12-23T09:34:32.000+0100}, author = {Jung, Alexander and Staat, Manfred}, biburl = {https://www.bibsonomy.org/bibtex/293add6bab52b8b039e8338f37720e9b9/staat}, doi = {10.1002/gamm.201900002}, interhash = {34b179db661c99ea591a85264f440874}, intrahash = {93add6bab52b8b039e8338f37720e9b9}, issn = {09367195}, journal = {GAMM-Mitteilungen}, keywords = {cardiomyocytes,multi-scale computer coupling,fibroblasts,hiPSC-derived electromechanical model,pharmacology}, month = nov, number = 4, pages = {e201900002}, timestamp = {2019-12-23T09:34:32.000+0100}, title = {{Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue}}, url = {https://onlinelibrary.wiley.com/doi/full/10.1002/gamm.201900002 http://doi.wiley.com/10.1002/gamm.201900002}, volume = 42, year = 2019 }