%0 Journal Article %1 Schmidt2003 %A Schmidt, Barbara %A Asztalos, Elizabeth V %A Roberts, Robin S %A Robertson, Charlene M T %A Sauve, Reginald S %A Whitfield, Michael F %A of Indomethacin Prophylaxis in Preterms (TIPP) Investigators, Trial %D 2003 %J JAMA %K Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cerebral Palsy; Cognition Disorders; Female; Gestational Age; Hearing Loss; Humans; Indomethacin; Infant; Infant, Newborn; Premature; Premature, Very Low Birth Weight; Logistic Models; Male; Morbidity; Prognosis; Retinopathy of Prematurity; Socioeconomic Factors; Survival Analysis %N 9 %P 1124--1129 %T Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. %V 289 %X CONTEXT: Despite more than 2 decades of outcomes research after very preterm birth, clinicians remain uncertain about the extent to which neonatal morbidities predict poor long-term outcomes of extremely low-birth-weight (ELBW) infants. OBJECTIVE: To determine the individual and combined prognostic effects of bronchopulmonary dysplasia (BPD), ultrasonographic signs of brain injury, and severe retinopathy of prematurity (ROP) on 18-month outcomes of ELBW infants. DESIGN: Inception cohort assembled for the Trial of Indomethacin Prophylaxis in Preterms (TIPP). SETTING AND PARTICIPANTS: A total of 910 infants with birth weights of 500 to 999 g who were admitted to 1 of 32 neonatal intensive care units in Canada, the United States, Australia, New Zealand, and Hong Kong between 1996 and 1998 and who survived to a postmenstrual age of 36 weeks. MAIN OUTCOME MEASURES: Combined end point of death or survival to 18 months with 1 or more of cerebral palsy, cognitive delay, severe hearing loss, and bilateral blindness. RESULTS: Each of the neonatal morbidities was similarly and independently correlated with a poor 18-month outcome. Odds ratios were 2.4 (95\% confidence interval CI, 1.8-3.2) for BPD, 3.7 (95\% CI, 2.6-5.3) for brain injury, and 3.1 (95\% CI, 1.9-5.0) for severe ROP. In children who were free of BPD, brain injury, and severe ROP the rate of poor long-term outcomes was 18\% (95\% CI, 14\%-22\%). Corresponding rates with any 1, any 2, and all 3 neonatal morbidities were 42\% (95\% CI, 37\%-47\%), 62\% (95\% CI, 53\%-70\%), and 88\% (64\%-99\%), respectively. CONCLUSION: In ELBW infants who survive to a postmenstrual age of 36 weeks, a simple count of 3 common neonatal morbidities strongly predicts the risk of later death or neurosensory impairment.

@article{Schmidt2003, abstract = {CONTEXT: Despite more than 2 decades of outcomes research after very preterm birth, clinicians remain uncertain about the extent to which neonatal morbidities predict poor long-term outcomes of extremely low-birth-weight (ELBW) infants. OBJECTIVE: To determine the individual and combined prognostic effects of bronchopulmonary dysplasia (BPD), ultrasonographic signs of brain injury, and severe retinopathy of prematurity (ROP) on 18-month outcomes of ELBW infants. DESIGN: Inception cohort assembled for the Trial of Indomethacin Prophylaxis in Preterms (TIPP). SETTING AND PARTICIPANTS: A total of 910 infants with birth weights of 500 to 999 g who were admitted to 1 of 32 neonatal intensive care units in Canada, the United States, Australia, New Zealand, and Hong Kong between 1996 and 1998 and who survived to a postmenstrual age of 36 weeks. MAIN OUTCOME MEASURES: Combined end point of death or survival to 18 months with 1 or more of cerebral palsy, cognitive delay, severe hearing loss, and bilateral blindness. RESULTS: Each of the neonatal morbidities was similarly and independently correlated with a poor 18-month outcome. Odds ratios were 2.4 (95\% confidence interval [CI], 1.8-3.2) for BPD, 3.7 (95\% CI, 2.6-5.3) for brain injury, and 3.1 (95\% CI, 1.9-5.0) for severe ROP. In children who were free of BPD, brain injury, and severe ROP the rate of poor long-term outcomes was 18\% (95\% CI, 14\%-22\%). Corresponding rates with any 1, any 2, and all 3 neonatal morbidities were 42\% (95\% CI, 37\%-47\%), 62\% (95\% CI, 53\%-70\%), and 88\% (64\%-99\%), respectively. CONCLUSION: In ELBW infants who survive to a postmenstrual age of 36 weeks, a simple count of 3 common neonatal morbidities strongly predicts the risk of later death or neurosensory impairment.}, added-at = {2014-07-19T21:17:22.000+0200}, author = {Schmidt, Barbara and Asztalos, Elizabeth V and Roberts, Robin S and Robertson, Charlene M T and Sauve, Reginald S and Whitfield, Michael F and of Indomethacin Prophylaxis in Preterms (TIPP) Investigators, Trial}, biburl = {https://www.bibsonomy.org/bibtex/250962d2eba9ff08db8e425afaaa9819d/ar0berts}, groups = {public}, interhash = {367ccf9738e831ef9f1f08c16666c758}, intrahash = {50962d2eba9ff08db8e425afaaa9819d}, journal = {JAMA}, keywords = {Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cerebral Palsy; Cognition Disorders; Female; Gestational Age; Hearing Loss; Humans; Indomethacin; Infant; Infant, Newborn; Premature; Premature, Very Low Birth Weight; Logistic Models; Male; Morbidity; Prognosis; Retinopathy of Prematurity; Socioeconomic Factors; Survival Analysis}, month = Mar, number = 9, pages = {1124--1129}, pmid = {12622582}, timestamp = {2014-07-19T21:17:22.000+0200}, title = {Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.}, username = {ar0berts}, volume = 289, year = 2003 }