%0 Journal Article %1 gos2008conditional %A Gos, Gesseca %A Wright, Stephen I %D 2008 %I Blackwell Publishing Ltd %J Molecular Ecology %K arabidopsis disease_resistance examples parallel_adaptation spatial_structure %N 23 %P 4953--4962 %R 10.1111/j.1365-294X.2008.03968.x %T Conditional neutrality at two adjacent NBS-LRR disease resistance loci in natural populations of Arabidopsis lyrata %U http://dx.doi.org/10.1111/j.1365-294X.2008.03968.x %V 17 %X Abstract We examined patterns of nucleotide diversity at a genomic region containing two linked candidate disease resistance (NBS-LRR) genes in seven populations of the outcrossing plant Arabidopsis lyrata. In comparison with two adjacent control genes and neutral reference genes across the genome, the NBS-LRR genes exhibited elevated nonsynonymous variation and a large number of major-effect polymorphisms causing early stop codons and/or frameshift mutations. In contrast, analysis of synonymous diversity provided no evidence that the region was subject to long-term balancing selection or recent selective sweeps in any of the seven populations surveyed. Also in contrast with earlier surveys of one of these R genes, there was no evidence that the resistance genes or the major-effect mutations were subject to elevated differentiation between populations. We suggest that conditional neutrality in the absence of the corresponding pathogen, rather than long-term balancing selection or local adaptation, may in some circumstances be a significant cause of elevated functional polymorphism at R genes. In contrast with the R genes, analysis of diversity and differentiation at the flanking FERONIA locus showed high population divergence, suggesting local adaptation on this locus controlling male–female signalling during fertilization.

@article{gos2008conditional, abstract = {Abstract We examined patterns of nucleotide diversity at a genomic region containing two linked candidate disease resistance (NBS-LRR) genes in seven populations of the outcrossing plant Arabidopsis lyrata. In comparison with two adjacent control genes and neutral reference genes across the genome, the NBS-LRR genes exhibited elevated nonsynonymous variation and a large number of major-effect polymorphisms causing early stop codons and/or frameshift mutations. In contrast, analysis of synonymous diversity provided no evidence that the region was subject to long-term balancing selection or recent selective sweeps in any of the seven populations surveyed. Also in contrast with earlier surveys of one of these R genes, there was no evidence that the resistance genes or the major-effect mutations were subject to elevated differentiation between populations. We suggest that conditional neutrality in the absence of the corresponding pathogen, rather than long-term balancing selection or local adaptation, may in some circumstances be a significant cause of elevated functional polymorphism at R genes. In contrast with the R genes, analysis of diversity and differentiation at the flanking FERONIA locus showed high population divergence, suggesting local adaptation on this locus controlling male–female signalling during fertilization.}, added-at = {2011-04-27T21:05:55.000+0200}, author = {Gos, Gesseca and Wright, Stephen I}, biburl = {https://www.bibsonomy.org/bibtex/209345236ebd70c237870281abd4e99b0/peter.ralph}, description = {Conditional neutrality at two adjacent NBS-LRR disease resistance loci in natural populations of Arabidopsis lyrata - GOS - 2008 - Molecular Ecology - Wiley Online Library}, doi = {10.1111/j.1365-294X.2008.03968.x}, interhash = {40f240f84a49703a937f156d3325a9db}, intrahash = {09345236ebd70c237870281abd4e99b0}, issn = {1365-294X}, journal = {Molecular Ecology}, keywords = {arabidopsis disease_resistance examples parallel_adaptation spatial_structure}, number = 23, pages = {4953--4962}, publisher = {Blackwell Publishing Ltd}, timestamp = {2011-04-27T21:05:55.000+0200}, title = {Conditional neutrality at two adjacent NBS-LRR disease resistance loci in natural populations of Arabidopsis lyrata}, url = {http://dx.doi.org/10.1111/j.1365-294X.2008.03968.x}, volume = 17, year = 2008 }