%0 Journal Article %1 Jansen2009Chemogenomic %A Jansen, Gregor %A Lee, Anna Y. %A Epp, Elias %A Fredette, Amelie %A Surprenant, Jamie %A Harcus, Doreen %A Scott, Michelle %A Tan, Elaine %A Nishimura, Tamiko %A Whiteway, Malcolm %A Hallett, Michael %A Thomas, David Y. %D 2009 %I Nature Publishing Group %J Molecular Systems Biology %K drug-interactions %N 1 %R 10.1038/msb.2009.95 %T Chemogenomic profiling predicts antifungal synergies %U http://dx.doi.org/10.1038/msb.2009.95 %V 5 %X Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies.

@article{Jansen2009Chemogenomic, abstract = {Chemotherapies, {HIV} infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Jansen, Gregor and Lee, Anna Y. and Epp, Elias and Fredette, Amelie and Surprenant, Jamie and Harcus, Doreen and Scott, Michelle and Tan, Elaine and Nishimura, Tamiko and Whiteway, Malcolm and Hallett, Michael and Thomas, David Y.}, biburl = {https://www.bibsonomy.org/bibtex/28b6bf692f2fee404a2fa1d23b17869e1/karthikraman}, citeulike-article-id = {6457970}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/msb.2009.95}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/msb200995}, day = 22, doi = {10.1038/msb.2009.95}, interhash = {436580bbff095232af3c69aaba499d9a}, intrahash = {8b6bf692f2fee404a2fa1d23b17869e1}, journal = {Molecular Systems Biology}, keywords = {drug-interactions}, month = dec, number = 1, posted-at = {2010-02-05 09:05:39}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Chemogenomic profiling predicts antifungal synergies}, url = {http://dx.doi.org/10.1038/msb.2009.95}, volume = 5, year = 2009 }