Article,
Intermediate filaments in cell migration and invasion: the unusual suspects
Current Opinion in Cell Biology, (2015)Cell architecture.
DOI: http://dx.doi.org/10.1016/j.ceb.2015.01.005
Abstract
Cell migration is a multistep process which relies on the coordination of cytoskeletal structures in space and time. While the roles of actin and microtubules have been investigated in great details, the lack of inhibitors and visualizing tools and the large number of proteins forming intermediate filaments (IFs) have delayed the characterization of \IF\ functions during migration. However, a large body of evidence has progressively pointed to changes in \IF\ composition as an important parameter in the regulation of cell migratory properties both during development and tumor invasion. More recent in-depth analyses show that \IFs\ are dynamically reorganized to participate, together with microfilaments and microtubules, to the key steps leading to cell migration.
