%0 Journal Article %1 becerratorres2014allium %A Becerra-Torres, Sergio L. %A Soria-Fregozo, César %A Jaramillo-Juárez, Fernando %A Moreno-Hernández-Duque, José L. %D 2014 %E JPPRes, %J Journal of Pharmacy & Pharmacognosy Research %K aclaramiento creatinina creatinine extracto-de-ajo garlic-extract inulin inulina malondialdehyde malondialdehído proteinuria renal-clearance %N 2 %P 45-52 %T Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats │El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidación lipídica inducida por dicromato de potasio en ratas %U http://jppres.com/jppres/pdf/vol2/jppres14.020_2.2.45.pdf %V 2 %X Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats. Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured. Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers. Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal.

@article{becerratorres2014allium, abstract = {Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats. Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured. Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers. Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal. }, added-at = {2014-04-27T09:21:25.000+0200}, author = {Becerra-Torres, Sergio L. and Soria-Fregozo, César and Jaramillo-Juárez, Fernando and Moreno-Hernández-Duque, José L.}, biburl = {https://www.bibsonomy.org/bibtex/2a5746732a02f936b1259db5e67f59d62/jppres}, editor = {JPPRes}, interhash = {4a785f480bb5eb76d67a410b286bce6f}, intrahash = {a5746732a02f936b1259db5e67f59d62}, journal = {Journal of Pharmacy & Pharmacognosy Research}, keywords = {aclaramiento creatinina creatinine extracto-de-ajo garlic-extract inulin inulina malondialdehyde malondialdehído proteinuria renal-clearance}, month = {April}, number = 2, pages = {45-52}, timestamp = {2014-04-27T09:22:51.000+0200}, title = {Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats │[El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidación lipídica inducida por dicromato de potasio en ratas]}, url = {http://jppres.com/jppres/pdf/vol2/jppres14.020_2.2.45.pdf}, volume = 2, year = 2014 }