%0 Journal Article %1 Sarkisyan:2010:Behav-Brain-Res:20097233 %A Sarkisyan, G %A Roberts, A J %A Hedlund, P B %D 2010 %J Behav Brain Res %K GBR antidepressant behavior forced_swimming %N 1 %P 99-108 %R 10.1016/j.bbr.2010.01.022 %T The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior %U http://www.ncbi.nlm.nih.gov/pubmed/20097233 %V 209 %X The 5-HT(7) receptor has been suggested as a target for treating depression since inactivation or blockade of the receptor has an antidepressant-like behavioral effect. The present study investigated possible interactions between various classes of drugs with antidepressant properties and blockade or inactivation of the 5-HT(7) receptor. Immobility despair in the tail suspension test and the forced swim test was evaluated in mice lacking the 5-HT(7) receptor (5-HT(7)(-/-)) and in wild-type controls (5-HT(7)(+/+)) following acute drug treatments. Citalopram, a selective serotonin reuptake inhibitor and widely used antidepressant, dose-dependently reduced immobility in the tail suspension test in both 5-HT(7)(+/+) and 5-HT(7)(-/-) mice. Combining doses of citalopram and the 5-HT(7) receptor antagonist SB-269970 that by themselves did not affect behavior, reduced immobility in 5-HT(7)(+/+) mice in both the tail suspension test and the forced swim test. No effect was seen in 5-HT(7)(-/-) mice. Desipramine and reboxetine, two norepinephrine reuptake inhibitors, dose-dependently reduced immobility in the tail suspension test in 5-HT(7)(+/+) mice, but had no effect in 5-HT(7)(-/-) mice. A synergistic effect between desipramine and SB-269970 was found in both behavioral tests in 5-HT(7)(+/+) mice. Reboxetine combined with SB-269970 had effect only in the forced swim test. GBR 12909, a dopamine reuptake inhibitor, dose-dependently reduced tail suspension test immobility in both genotypes. There was no interaction between GBR 12909 and SB-269970. Aripiprazole, an antipsychotic, reduced immobility in both tests in 5-HT(7)(+/+) mice, but not in 5-HT(7)(-/-) mice. The results show that the 5-HT(7) receptor is required for the observed interaction between this receptor and antidepressants such as citalopram. The data furthermore support the hypothesis that the 5-HT(7) receptor might be a suitable target for treating depression.

@article{Sarkisyan:2010:Behav-Brain-Res:20097233, abstract = {The 5-HT(7) receptor has been suggested as a target for treating depression since inactivation or blockade of the receptor has an antidepressant-like behavioral effect. The present study investigated possible interactions between various classes of drugs with antidepressant properties and blockade or inactivation of the 5-HT(7) receptor. Immobility despair in the tail suspension test and the forced swim test was evaluated in mice lacking the 5-HT(7) receptor (5-HT(7)(-/-)) and in wild-type controls (5-HT(7)(+/+)) following acute drug treatments. Citalopram, a selective serotonin reuptake inhibitor and widely used antidepressant, dose-dependently reduced immobility in the tail suspension test in both 5-HT(7)(+/+) and 5-HT(7)(-/-) mice. Combining doses of citalopram and the 5-HT(7) receptor antagonist SB-269970 that by themselves did not affect behavior, reduced immobility in 5-HT(7)(+/+) mice in both the tail suspension test and the forced swim test. No effect was seen in 5-HT(7)(-/-) mice. Desipramine and reboxetine, two norepinephrine reuptake inhibitors, dose-dependently reduced immobility in the tail suspension test in 5-HT(7)(+/+) mice, but had no effect in 5-HT(7)(-/-) mice. A synergistic effect between desipramine and SB-269970 was found in both behavioral tests in 5-HT(7)(+/+) mice. Reboxetine combined with SB-269970 had effect only in the forced swim test. GBR 12909, a dopamine reuptake inhibitor, dose-dependently reduced tail suspension test immobility in both genotypes. There was no interaction between GBR 12909 and SB-269970. Aripiprazole, an antipsychotic, reduced immobility in both tests in 5-HT(7)(+/+) mice, but not in 5-HT(7)(-/-) mice. The results show that the 5-HT(7) receptor is required for the observed interaction between this receptor and antidepressants such as citalopram. The data furthermore support the hypothesis that the 5-HT(7) receptor might be a suitable target for treating depression.}, added-at = {2013-05-23T16:24:10.000+0200}, author = {Sarkisyan, G and Roberts, A J and Hedlund, P B}, biburl = {https://www.bibsonomy.org/bibtex/2f94d1c4834b208696c48de21ed236726/kilianjay}, description = {The 5-HT(7) receptor as a mediator and modul... [Behav Brain Res. 2010] - PubMed - NCBI}, doi = {10.1016/j.bbr.2010.01.022}, interhash = {4f4f833ab49a9a5e1acefa6abf0aa198}, intrahash = {f94d1c4834b208696c48de21ed236726}, journal = {Behav Brain Res}, keywords = {GBR antidepressant behavior forced_swimming}, month = may, number = 1, pages = {99-108}, pmid = {20097233}, timestamp = {2013-05-23T16:24:10.000+0200}, title = {The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20097233}, volume = 209, year = 2010 }