Аннотация
The reaction of K-2PtCl4 and K-2PtCl6 with
5-methyl-5-(2-pyridyl)-2,4-imidazolidenedione (L) proceeded with the
deprotonation of L forming Pt(II) and Pt(IV) complexes,
KPtCl2(N,N-L) (1) and KPtCl4(N,N-L) (2), respectively. Within
several weeks in DMSO/CH3OH solution of both complexes 1 and 2 the
crystalline platinum(II) complex, PtCl(N, N-L)(DMSO) (3), was obtained,
corresponded to a substitution reaction (on 1 and 2) and unanticipated
reduction (on 2). The nature of the reducing agent is unknown. Single
crystal X-ray diffraction analysis proved bidentate N-coordinated
fashion and square planar arrangement for L and 3, respectively. The
quantum chemical calculations supported the crystal packing findings in
which intermolecular classical and non-classical hydrogen bonds was
found. The reaction of L with K-2PdCl4 and PdCl2 gave the same
complex of palladium(II) with 2:1 ligand-metal ratio, Pd(N,N-L)(2) (4).
DFT studies showed the intramolecular hydrogen bonding has significant
effect on the stabilization of trans isomer for this complex.
Antibacterial studies against six bacterial strains showed main
compounds L, 3, and 4 represent activity with low levels of inhibitory
potency. In vitro cytotoxicity studies in MCF-7 and A-549 tumor cell
lines on 3 were in accordance with the reported data, the substitution
of one chlorido ligand with DMSO molecule highly inactivates in vitro
antitumor activity. (C) 2013 Elsevier B.V. All rights reserved.
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