%0 Journal Article %1 Falchi2009265 %A Falchi, Alessandra %A Varesi, Laurent %A Arena, Christophe %A Leveque, Nicolas %A Renois, Fanny %A Blanchon, Thierry %A Amoros, Jean Pierre %A Andreoletti, Laurent %D 2009 %J Journal of Clinical Virology %K antigenic influenza surveillance %N 3 %P 265--268 %R DOI: 10.1016/j.jcv.2009.05.004 %T Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France %U http://www.sciencedirect.com/science/article/B6VJV-4WGHJST-1/2/7463a09a63b3855aa63ec31a304ca789 %V 45 %X Background Influenza virus is one of the major viral respiratory pathogens infecting human beings.Objectives To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France.Study design Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1.Results All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients.Conclusion These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.

@article{Falchi2009265, abstract = {Background Influenza virus is one of the major viral respiratory pathogens infecting human beings.Objectives To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France.Study design Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1.Results All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients.Conclusion These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.}, added-at = {2009-08-04T18:25:01.000+0200}, author = {Falchi, Alessandra and Varesi, Laurent and Arena, Christophe and Leveque, Nicolas and Renois, Fanny and Blanchon, Thierry and Amoros, Jean Pierre and Andreoletti, Laurent}, biburl = {https://www.bibsonomy.org/bibtex/2a9b59ec71db0578bb943fa8b257047f7/ebo}, description = {ScienceDirect - Journal of Clinical Virology : Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006–2007 epidemic season in Corsica Island, France}, doi = {DOI: 10.1016/j.jcv.2009.05.004}, interhash = {5152097cd19c33041156bb835660393a}, intrahash = {a9b59ec71db0578bb943fa8b257047f7}, issn = {1386-6532}, journal = {Journal of Clinical Virology}, keywords = {antigenic influenza surveillance}, note = {Special section: Novel 2009 influenza A H1N1 (swine variant)}, number = 3, pages = {265--268}, timestamp = {2009-08-04T18:25:01.000+0200}, title = {Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France}, url = {http://www.sciencedirect.com/science/article/B6VJV-4WGHJST-1/2/7463a09a63b3855aa63ec31a304ca789}, volume = 45, year = 2009 }