Abstract
Ryanodine receptors (RyRs), a class of intracellular calcium release
channels, are the largest ion channels known. Recently, cryoelectron
microscopy and image reconstructions of isolated receptors have shown
that most of the protein mass forms a porous, multidomain cytoplasmic
assembly. Evidence is mounting that suggests that the cytoplasmic
assembly communicates with the transmembrane regions over distances
of 100 or greater. RyRs are centrally important in excitation-contraction
coupling, which occurs at specialized regions where the sarcoplasmic
reticulum, containing the RyRs, and the plasma membrane/transverse-tubule
system form junctions. Numerous proteins are present at these junctions,
some of which interact directly with the RyR.
- 9094329
- animals,
- binding
- calcium
- calmodulin,
- calmodulin-bindi,
- carrier
- channel,
- channels,
- conformation,
- dna-binding
- electron,
- freezing,
- gov't,
- heat-shock
- humans,
- macromolecular
- microscopy,
- models,
- molecular,
- muscle
- muscle,
- ng
- non-u.s.
- ns,
- p.h.s.,
- protei,
- protein
- proteins,
- rabbits,
- receptor
- release
- research
- ryanodine
- skeletal,
- substances,
- support,
- tacrolimus
- u.s.
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