%0 Journal Article %1 Butler2004 %A Butler, Robert N %A Sprott, Richard %A Warner, Huber %A Bland, Jeffrey %A Feuers, Richie %A Forster, Michael %A Fillit, Howard %A Harman, S Mitchell %A Hewitt, Michael %A Hyman, Mark %A Johnson, Kathleen %A Kligman, Evan %A McClearn, Gerald %A Nelson, James %A Richardson, Arlan %A Sonntag, William %A Weindruch, Richard %A Wolf, Norman %D 2004 %J The Journals of Gerontology Series A: Biological Sciences and Medical Sciences %K aging biomarkers %N 6 %P B560--B567 %T Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans %U http://biomedgerontology.oxfordjournals.org/content/59/6/B560.abstract %V 59 %X Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large. While there was not total agreement on all issues, they addressed a number of questions, among them whether biomarkers can be identified and used to measure the physiological age of any individual within a population, given emerging information about aging and new technological advances. The hurdles to establishing informative biomarkers include the biological variation between individuals that makes generalizations difficult; the overlapping of aging and disease processes; uncertainty regarding benign versus pathogenic age-related changes; the point at which a process begins to do damage to the organism, and, if so, when does it occur; and when to distinguish critical damage from noncritical damage. Finally, and significantly, it is difficult to obtain funding for this research.

@article{Butler2004, abstract = {Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large. While there was not total agreement on all issues, they addressed a number of questions, among them whether biomarkers can be identified and used to measure the physiological age of any individual within a population, given emerging information about aging and new technological advances. The hurdles to establishing informative biomarkers include the biological variation between individuals that makes generalizations difficult; the overlapping of aging and disease processes; uncertainty regarding benign versus pathogenic age-related changes; the point at which a process begins to do damage to the organism, and, if so, when does it occur; and when to distinguish critical damage from noncritical damage. Finally, and significantly, it is difficult to obtain funding for this research.}, added-at = {2012-11-08T12:19:33.000+0100}, author = {Butler, Robert N and Sprott, Richard and Warner, Huber and Bland, Jeffrey and Feuers, Richie and Forster, Michael and Fillit, Howard and Harman, S Mitchell and Hewitt, Michael and Hyman, Mark and Johnson, Kathleen and Kligman, Evan and McClearn, Gerald and Nelson, James and Richardson, Arlan and Sonntag, William and Weindruch, Richard and Wolf, Norman}, biburl = {https://www.bibsonomy.org/bibtex/22d1f0b62b371d002472f5116bc421e74/jabreftest}, file = {Butler2004_00.pdf:Butler2004_00.pdf:PDF}, groups = {public}, interhash = {53e2154a4b80a65a9600bbdd63f07c82}, intrahash = {2d1f0b62b371d002472f5116bc421e74}, journal = {The Journals of Gerontology Series A: Biological Sciences and Medical Sciences}, keywords = {aging biomarkers}, number = 6, pages = {B560--B567}, timestamp = {2012-11-08T12:19:33.000+0100}, title = {{Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans}}, type = {10.1093/gerona/59.6.B560}, url = {http://biomedgerontology.oxfordjournals.org/content/59/6/B560.abstract}, username = {jabreftest}, volume = 59, year = 2004 }