%0 Journal Article %1 RefWorks:2924 %A Botha, P. %A Archer, L. %A Anderson, R. L. %A Lordan, J. %A Dark, J. H. %A Corris, P. A. %A Gould, K. %A Fisher, A. J. %D 2008 %J Transplantation %K pseudomonas bos balf transplantation rejection %N 5 %P 771-774 %T Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome %V 85 %X Long-term survival after lung transplantation remains limited by the development of bronchiolitis obliterans syndrome (BOS). Allograft colonization with Pseudomonas aeruginosa is common particularly in recipients with BOS, but a possible etiological relationship remains unexplored. In 155 consecutive lung transplants, the development of allograft colonization with Pseudomonas was strongly associated with the development of BOS within 2 years of transplant (23.4% vs. 7.7% in those colonized and not colonized, respectively, P=0.006). Freedom from BOS was significantly shorter in those patients without any pretransplant bacterial reservoir developing de novo allograft pseudomonal colonization as compared with those remaining free of colonization (Kaplan-Meier log-rank P=0.014). The isolation of Pseudomonas preceded the diagnosis of BOS in 14 of 18 (78%) and by a median of 204 days (95% confidence interval 115-492) in patients developing both these complications. We conclude that de novo colonization of the lung allograft by Pseudomonas is strongly associated with the subsequent development of BOS. %@ 0041-1337; 0041-1337

@article{RefWorks:2924, abstract = {Long-term survival after lung transplantation remains limited by the development of bronchiolitis obliterans syndrome (BOS). Allograft colonization with Pseudomonas aeruginosa is common particularly in recipients with BOS, but a possible etiological relationship remains unexplored. In 155 consecutive lung transplants, the development of allograft colonization with Pseudomonas was strongly associated with the development of BOS within 2 years of transplant (23.4% vs. 7.7% in those colonized and not colonized, respectively, P=0.006). Freedom from BOS was significantly shorter in those patients without any pretransplant bacterial reservoir developing de novo allograft pseudomonal colonization as compared with those remaining free of colonization (Kaplan-Meier log-rank P=0.014). The isolation of Pseudomonas preceded the diagnosis of BOS in 14 of 18 (78%) and by a median of 204 days (95% confidence interval 115-492) in patients developing both these complications. We conclude that de novo colonization of the lung allograft by Pseudomonas is strongly associated with the subsequent development of BOS.}, added-at = {2013-04-11T00:02:48.000+0200}, author = {Botha, P. and Archer, L. and Anderson, R. L. and Lordan, J. and Dark, J. H. and Corris, P. A. and Gould, K. and Fisher, A. J.}, biburl = {https://www.bibsonomy.org/bibtex/2e86170f46868fa4701fdeb02185a95c1/aorchid}, description = {see page 27 of notebook 00002 and our article}, file = {:allorejection/Transplantation.85.771.pdf:PDF}, groups = {public}, interhash = {561c68a1f24446bac400ad147932d5a1}, intrahash = {e86170f46868fa4701fdeb02185a95c1}, isbn = {0041-1337; 0041-1337}, journal = {Transplantation}, keywords = {pseudomonas bos balf transplantation rejection}, language = {eng}, month = {Mar 15}, note = {LR: 20080925; JID: 0132144; CIN: Transplantation. 2008 Aug 27;86(4):624-5; author reply 635-6. PMID: 18724236; ppublish}, number = 5, pages = {771-774}, timestamp = {2013-04-11T00:02:48.000+0200}, title = {Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome}, username = {aorchid}, volume = 85, year = 2008 }