%0 Journal Article %1 staubach2012genome %A Staubach, Fabian %A Lorenc, Anna %A Messer, Philipp W. %A Tang, Kun %A Petrov, Dmitri A. %A Tautz, Diethard %D 2012 %I Public Library of Science %J PLoS Genet %K Mus clines haplotypes hybrid_filter hybrid_zone introgression population_genomics selection %N 8 %P e1002891 %R 10.1371/journal.pgen.1002891 %T Genome Patterns of Selection and Introgression of Haplotypes in Natural Populations of the House Mouse (Mus musculus) %U http://dx.doi.org/10.1371%2Fjournal.pgen.1002891 %V 8 %X Although there is abundant evidence for phenotypic adaptation in natural populations, it is still a challenge to understand the underlying genetic processes. House mice have colonized the world in several successive waves, the most recent ones in the wake of the spread of human agriculture and trans-oceanic shipping. They have adapted to many habitats and climates, and their populations provide a rich source of opportunities for studying the impact of adaptation and positive selection on the genome. By scanning the whole genome of four natural populations of mice, we detect abundant evidence for recent positive selection, including loci that are known to be involved in genetic diseases in humans. Unexpectedly, we also find a high proportion of gene exchange between populations that have long been separated. This finding supports the notion that hybridization and transfer of alleles can significantly contribute to new genetic material subject to positive selection.

@article{staubach2012genome, abstract = {Although there is abundant evidence for phenotypic adaptation in natural populations, it is still a challenge to understand the underlying genetic processes. House mice have colonized the world in several successive waves, the most recent ones in the wake of the spread of human agriculture and trans-oceanic shipping. They have adapted to many habitats and climates, and their populations provide a rich source of opportunities for studying the impact of adaptation and positive selection on the genome. By scanning the whole genome of four natural populations of mice, we detect abundant evidence for recent positive selection, including loci that are known to be involved in genetic diseases in humans. Unexpectedly, we also find a high proportion of gene exchange between populations that have long been separated. This finding supports the notion that hybridization and transfer of alleles can significantly contribute to new genetic material subject to positive selection.}, added-at = {2012-09-05T20:56:23.000+0200}, author = {Staubach, Fabian and Lorenc, Anna and Messer, Philipp W. and Tang, Kun and Petrov, Dmitri A. and Tautz, Diethard}, biburl = {https://www.bibsonomy.org/bibtex/2cc74f6ae6889403892cf6dc66592f84f/peter.ralph}, doi = {10.1371/journal.pgen.1002891}, interhash = {5a6f27aab83e2a074e7364d06ab0bb4d}, intrahash = {cc74f6ae6889403892cf6dc66592f84f}, journal = {PLoS Genet}, keywords = {Mus clines haplotypes hybrid_filter hybrid_zone introgression population_genomics selection}, month = {08}, number = 8, pages = {e1002891}, publisher = {Public Library of Science}, timestamp = {2012-09-05T20:56:23.000+0200}, title = {Genome Patterns of Selection and Introgression of Haplotypes in Natural Populations of the House Mouse ({\it {Mus} musculus})}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1002891}, volume = 8, year = 2012 }