%0 Journal Article %1 Gessler.1993 %A Gessler, M. %A Bruns, G. A. %D 1993 %J Genomics %K (Genetics) *Promoter Acid Amino Animals Base Box DNA-Binding DNA;Complementary/metabolism Data Fetus Fingers/genetics Homology;Amino Humans Kidney Kidney/metabolism Mapping Mice Molecular Neoplasms/*genetics Proteins Proteins/*genetics Regions Restriction Sequence TATA Transcription;Genetic Tumor/*genetics WT1 Wilms Zinc %N 2 %P 499--501 %T Sequence of the WT1 upstream region including the Wit-1 gene %V 17 %X The Wilms tumor gene WT1 encodes a Cys2His2-type zinc finger protein that can bind DNA and function as a transcriptional regulator. The pathological spectrum of tumorigenesis and various developmental defects produced by different WT1 alterations suggests that WT1 controls a number of subsequent effector genes. To define the role of WT1 in these developmental processes it will be important to elucidate mechanisms that govern expression of WT1 itself. To facilitate mapping of the WT1 promoter region and 5' control elements we have determined the sequence upstream of the WT1 transcription unit. This includes the Wit-1 gene that is transcribed in the opposite direction.

@article{Gessler.1993, abstract = {The Wilms tumor gene WT1 encodes a Cys2His2-type zinc finger protein that can bind DNA and function as a transcriptional regulator. The pathological spectrum of tumorigenesis and various developmental defects produced by different WT1 alterations suggests that WT1 controls a number of subsequent effector genes. To define the role of WT1 in these developmental processes it will be important to elucidate mechanisms that govern expression of WT1 itself. To facilitate mapping of the WT1 promoter region and 5' control elements we have determined the sequence upstream of the WT1 transcription unit. This includes the Wit-1 gene that is transcribed in the opposite direction.}, added-at = {2013-01-29T13:47:26.000+0100}, author = {Gessler, M. and Bruns, G. A.}, biburl = {https://www.bibsonomy.org/bibtex/2772472c8827d69e820c7f2758eb963df/ebch}, interhash = {5bc2b2aca6f454fc892fc8c13c7e3b1f}, intrahash = {772472c8827d69e820c7f2758eb963df}, journal = {Genomics}, keywords = {(Genetics) *Promoter Acid Amino Animals Base Box DNA-Binding DNA;Complementary/metabolism Data Fetus Fingers/genetics Homology;Amino Humans Kidney Kidney/metabolism Mapping Mice Molecular Neoplasms/*genetics Proteins Proteins/*genetics Regions Restriction Sequence TATA Transcription;Genetic Tumor/*genetics WT1 Wilms Zinc}, number = 2, pages = {499--501}, timestamp = {2013-01-29T13:47:43.000+0100}, title = {Sequence of the WT1 upstream region including the Wit-1 gene}, volume = 17, year = 1993 }