Abstract
Evaluation of morphological differences between primary tumors and their intracerebral metastases was
performed in operational specimens from 41 patients with intracerebral metastases (carcinoma in
80,5±6,19 %, melanoma in 19,5±6,19 %) and primary tumors: skin melanoma (8 cases), lungs carcinoma
(17 cases), breast carcinoma (16 cases). Standard basic micromorphological processing was performed.
The structure of intracerebral metastatic melanoma foci had similarities with primary foci, but with higher
atypicity, vascularity, surrounding by "muffs" of tumor cells, hemorrhagic, inflammatory and necrotic foci.
Tumor tissue of lungs-derived metastatic focus repeated the structure of primary tumor, in patches
glandular formations go with solid layers of acinar structures in the center, stroma in these places is not
prominent giving an evidence of de-differentiation. In primary breast tumors and their brain metastases
morphology was almost identical. It was proved that brain metastatic tumor tissue is characterized by
lower differentiation comparing with primary tumor.
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