%0 Journal Article %1 pauls2021endocrine %A Pauls, D. %A Selcho, M. %A Raderscheidt, J. %A Amatobi, K. M. %A Fekete, A. %A Krischke, M. %A Hermann-Luibl, C. %A Ozbek-Unal, A. G. %A Ehmann, N. %A Itskov, P. M. %A Kittel, R. J. %A Helfrich-Forster, C. %A Kuhnlein, R. P. %A Mueller, M. J. %A Wegener, C. %D 2021 %J Curr Biol %K Animals myOwn uni_network %N 18 %P 4076-4087 e5 %R 10.1016/j.cub.2021.07.002 %T Endocrine signals fine-tune daily activity patterns in Drosophila %U https://www.ncbi.nlm.nih.gov/pubmed/34329588 %V 31 %X Animals need to balance competitive behaviors to maintain internal homeostasis. The underlying mechanisms are complex but typically involve neuroendocrine signaling. Using Drosophila, we systematically manipulated signaling between energy-mobilizing endocrine cells producing adipokinetic hormone (AKH), octopaminergic neurons, and the energy-storing fat body to assess whether this neuroendocrine axis involved in starvation-induced hyperactivity also balances activity levels under ad libitum access to food. Our results suggest that AKH signals via two divergent pathways that are mutually competitive in terms of activity and rest. AKH increases activity via the octopaminergic system during the day, while it prevents high activity levels during the night by signaling to the fat body. This regulation involves feedback signaling from octopaminergic neurons to AKH-producing cells (APCs). APCs are known to integrate a multitude of metabolic and endocrine signals. Our results add a new facet to the versatile regulatory functions of APCs by showing that their output contributes to shape the daily activity pattern under ad libitum access to food.

@article{pauls2021endocrine, abstract = {Animals need to balance competitive behaviors to maintain internal homeostasis. The underlying mechanisms are complex but typically involve neuroendocrine signaling. Using Drosophila, we systematically manipulated signaling between energy-mobilizing endocrine cells producing adipokinetic hormone (AKH), octopaminergic neurons, and the energy-storing fat body to assess whether this neuroendocrine axis involved in starvation-induced hyperactivity also balances activity levels under ad libitum access to food. Our results suggest that AKH signals via two divergent pathways that are mutually competitive in terms of activity and rest. AKH increases activity via the octopaminergic system during the day, while it prevents high activity levels during the night by signaling to the fat body. This regulation involves feedback signaling from octopaminergic neurons to AKH-producing cells (APCs). APCs are known to integrate a multitude of metabolic and endocrine signals. Our results add a new facet to the versatile regulatory functions of APCs by showing that their output contributes to shape the daily activity pattern under ad libitum access to food.}, added-at = {2024-02-15T15:08:22.000+0100}, author = {Pauls, D. and Selcho, M. and Raderscheidt, J. and Amatobi, K. M. and Fekete, A. and Krischke, M. and Hermann-Luibl, C. and Ozbek-Unal, A. G. and Ehmann, N. and Itskov, P. M. and Kittel, R. J. and Helfrich-Forster, C. and Kuhnlein, R. P. and Mueller, M. J. and Wegener, C.}, biburl = {https://www.bibsonomy.org/bibtex/29dc4424282e44e9c9ec6ede8b9c37538/jvsi_all}, doi = {10.1016/j.cub.2021.07.002}, interhash = {618203558d36298e1a4cfcbf91f32470}, intrahash = {9dc4424282e44e9c9ec6ede8b9c37538}, issn = {1879-0445 (Electronic) 0960-9822 (Linking)}, journal = {Curr Biol}, keywords = {Animals myOwn uni_network}, note = {Pauls, Dennis Selcho, Mareike Raderscheidt, Johanna Amatobi, Kelechi M Fekete, Agnes Krischke, Markus Hermann-Luibl, Christiane Ozbek-Unal, Ayten Gizem Ehmann, Nadine Itskov, Pavel M Kittel, Robert J Helfrich-Forster, Charlotte Kuhnlein, Ronald P Mueller, Martin J Wegener, Christian eng Research Support, Non-U.S. Gov't England 2021/07/31 Curr Biol. 2021 Sep 27;31(18):4076-4087.e5. doi: 10.1016/j.cub.2021.07.002. Epub 2021 Jul 29.}, number = 18, pages = {4076-4087 e5}, timestamp = {2024-02-15T15:11:55.000+0100}, title = {Endocrine signals fine-tune daily activity patterns in Drosophila}, type = {Journal Article}, url = {https://www.ncbi.nlm.nih.gov/pubmed/34329588}, volume = 31, year = 2021 }