%0 Journal Article %1 Offermanns1998 %A Offermanns, S. %A Zhao, L. P. %A Gohla, A. %A Sarosi, I. %A Simon, M. I. %A Wilkie, T. M. %D 1998 %J EMBO J %K Abnormalities/*embryology/*genetics/pathology Alleles Animals Animals, C57BL Congenital/*embryology/*genetics/mortality/pathology Craniofacial Crosses, Defects, Dosage GTP-Binding Gene Genetic Gohla Heart Knockout Mice Myocardium/*pathology Newborn/genetics Proteins/deficiency/*genetics Strains %N 15 %P 4304-12 %T Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9687499 %V 17 %X Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact allele G alpha q(-/+);G alpha 11(-/-) or G alpha q(-/-);G alpha 11(-/+) died shortly after birth. These mutants showed a high incidence of cardiac malformation. In addition, G alpha q(-/-);G alpha 11(-/+) newborns suffered from craniofacial defects. Mice lacking both G alpha q and G alpha 11 G alpha q(-/-);G alpha 11(-/-) died at embryonic day 11 due to cardiomyocyte hypoplasia. These data demonstrate overlap in G alpha q and G alpha 11 gene functions and indicate that the Gq class of G proteins plays a crucial role in cardiac growth and development.

@article{Offermanns1998, abstract = {Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact allele [G alpha q(-/+);G alpha 11(-/-) or G alpha q(-/-);G alpha 11(-/+)] died shortly after birth. These mutants showed a high incidence of cardiac malformation. In addition, G alpha q(-/-);G alpha 11(-/+) newborns suffered from craniofacial defects. Mice lacking both G alpha q and G alpha 11 [G alpha q(-/-);G alpha 11(-/-)] died at embryonic day 11 due to cardiomyocyte hypoplasia. These data demonstrate overlap in G alpha q and G alpha 11 gene functions and indicate that the Gq class of G proteins plays a crucial role in cardiac growth and development.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Offermanns, S. and Zhao, L. P. and Gohla, A. and Sarosi, I. and Simon, M. I. and Wilkie, T. M.}, biburl = {https://www.bibsonomy.org/bibtex/2bbdda8b8f4562cd8dc8fbccabb009fce/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {64b020e9a323260ea918471f849bd5f1}, intrahash = {bbdda8b8f4562cd8dc8fbccabb009fce}, issn = {0261-4189 (Print) 0261-4189 (Linking)}, journal = {EMBO J}, keywords = {Abnormalities/*embryology/*genetics/pathology Alleles Animals Animals, C57BL Congenital/*embryology/*genetics/mortality/pathology Craniofacial Crosses, Defects, Dosage GTP-Binding Gene Genetic Gohla Heart Knockout Mice Myocardium/*pathology Newborn/genetics Proteins/deficiency/*genetics Strains}, month = {Aug 3}, note = {Offermanns, S Zhao, L P Gohla, A Sarosi, I Simon, M I Wilkie, T M DK47890/DK/NIDDK NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England The EMBO journal EMBO J. 1998 Aug 3;17(15):4304-12.}, number = 15, pages = {4304-12}, shorttitle = {Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice}, timestamp = {2010-12-14T18:22:14.000+0100}, title = {Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9687499}, volume = 17, year = 1998 }