%0 Journal Article %1 Al-Maghrabi2016 %A Al-Maghrabi, Jaudah A. %A Butt, Nadeem S. %A Anfinan, Nisrin %A Sait, Khalid %A Sait, Hesham %A Marzouki, Anas %A Khabaz, Mohamad Nidal %D 2016 %J Applied Immunohistochemistry & Molecular Morphology %K imported %P 1 %R 10.1097/PAI.0000000000000350 %T Infrequent Immunohistochemical Expression of Napsin A in Endometrial Carcinomas %U http://www.ncbi.nlm.nih.gov/pubmed/26945446\%5Cnhttp://Insights.ovid.com/crossref?an=00129039-900000000-99117 %X INTRODUCTION Many studies described napsin A as a specific diagnostic marker that aids in differentiating lung adenocarcinomas from other respiratory tumors. This study describes the expression phenotype of napsin A in endometrial neoplasms, it investigates the relationship between this expression profile and the clinicopathologic parameters, and assess its utilization as an independent predictive marker. METHODS A total of 76 cases of previously diagnosed endometrial carcinoma (including 53 endometrioid adenocarcinomas, 6 endometrioid adenocarcinomas with squamous differentiation, 9 serous adenocarcinomas, 6 clear cell adenocarcinomas, and 2 malignant mixed mullerian tumors) and 30 tissue samples of noncancerous endometrium (including 16 proliferative endometriums, 10 secretory endometriums and 4 endometrial polyps) were retrieved from the archives of Pathology Department at King Abdulaziz University, Jeddah, Saudi Arabia. For napsin A detection, tissue microarrays and immunostaining were used. RESULTS A total number of 12 (15.78\%) cases were positive for napsin A immunostaining. Brown granular cytoplasmic expression of napsin A was detected in 9.4\% of endometrioid adenocarcinomas, 16.7\% of endometrioid adenocarcinomas with squamous differentiation, 22.2\% of papillary serous endometrial carcinomas, and 66.7\% of clear cell carcinomas. Three (10\%) control cases showed similar granular cytoplasmic expression. Positive napsin A immunostaining was more frequent in clear cell carcinoma, and there is a significant association between positive napsin A immunostaining and clear cell carcinoma (P-value=0.007). Significant associations have been found also between napsin A expression and older ages (above 60 y) and higher stage (IVB), the P-values of which were 0.035 and 0.043, respectively, but not with the tumor recurrence or survival rate. CONCLUSIONS Although napsin A is infrequently expressed in endometrial carcinomas, positive results of napsin A immunostaining in endometrial neoplasms might support the diagnosis of clear cell carcinoma when the pathologic differential diagnosis includes other histologic subtypes.

@article{Al-Maghrabi2016, abstract = {INTRODUCTION Many studies described napsin A as a specific diagnostic marker that aids in differentiating lung adenocarcinomas from other respiratory tumors. This study describes the expression phenotype of napsin A in endometrial neoplasms, it investigates the relationship between this expression profile and the clinicopathologic parameters, and assess its utilization as an independent predictive marker. METHODS A total of 76 cases of previously diagnosed endometrial carcinoma (including 53 endometrioid adenocarcinomas, 6 endometrioid adenocarcinomas with squamous differentiation, 9 serous adenocarcinomas, 6 clear cell adenocarcinomas, and 2 malignant mixed mullerian tumors) and 30 tissue samples of noncancerous endometrium (including 16 proliferative endometriums, 10 secretory endometriums and 4 endometrial polyps) were retrieved from the archives of Pathology Department at King Abdulaziz University, Jeddah, Saudi Arabia. For napsin A detection, tissue microarrays and immunostaining were used. RESULTS A total number of 12 (15.78{\%}) cases were positive for napsin A immunostaining. Brown granular cytoplasmic expression of napsin A was detected in 9.4{\%} of endometrioid adenocarcinomas, 16.7{\%} of endometrioid adenocarcinomas with squamous differentiation, 22.2{\%} of papillary serous endometrial carcinomas, and 66.7{\%} of clear cell carcinomas. Three (10{\%}) control cases showed similar granular cytoplasmic expression. Positive napsin A immunostaining was more frequent in clear cell carcinoma, and there is a significant association between positive napsin A immunostaining and clear cell carcinoma (P-value=0.007). Significant associations have been found also between napsin A expression and older ages (above 60 y) and higher stage (IVB), the P-values of which were 0.035 and 0.043, respectively, but not with the tumor recurrence or survival rate. CONCLUSIONS Although napsin A is infrequently expressed in endometrial carcinomas, positive results of napsin A immunostaining in endometrial neoplasms might support the diagnosis of clear cell carcinoma when the pathologic differential diagnosis includes other histologic subtypes.}, added-at = {2017-11-05T18:54:27.000+0100}, author = {Al-Maghrabi, Jaudah A. and Butt, Nadeem S. and Anfinan, Nisrin and Sait, Khalid and Sait, Hesham and Marzouki, Anas and Khabaz, Mohamad Nidal}, biburl = {https://www.bibsonomy.org/bibtex/2d40cec8da3a557080a9fec8838a8f406/nadeemshafique}, doi = {10.1097/PAI.0000000000000350}, interhash = {64be2f4786f06e1f1f0322489cbc9854}, intrahash = {d40cec8da3a557080a9fec8838a8f406}, issn = {1541-2016}, journal = {Applied Immunohistochemistry {\&} Molecular Morphology}, keywords = {imported}, pages = 1, pmid = {26945446}, timestamp = {2017-11-05T18:55:24.000+0100}, title = {{Infrequent Immunohistochemical Expression of Napsin A in Endometrial Carcinomas}}, url = {http://www.ncbi.nlm.nih.gov/pubmed/26945446{\%}5Cnhttp://Insights.ovid.com/crossref?an=00129039-900000000-99117}, year = 2016 }