%0 Journal Article %1 Politz2012Artificial %A Politz, Mark C. %A Copeland, Matthew F. %A Pfleger, Brian F. %D 2012 %J Chemical communications (Cambridge, England) %K bt3240 gene-expression %R 10.1039/c2cc37107c %T Artificial repressors for controlling gene expression in bacteria. %U http://dx.doi.org/10.1039/c2cc37107c %X Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.

@article{Politz2012Artificial, abstract = { Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered {DNA} binding protein based upon a transcription activator-like effector ({TALE}) scaffold was shown to outperform {LacI} in blocking transcription from a promoter and to repress expression of a downstream gene in an operon. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Politz, Mark C. and Copeland, Matthew F. and Pfleger, Brian F.}, biburl = {https://www.bibsonomy.org/bibtex/23990e5a26ba71ebff4f6e7254fc6cbb0/karthikraman}, citeulike-article-id = {12116174}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/c2cc37107c}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/23230569}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=23230569}, day = 10, doi = {10.1039/c2cc37107c}, interhash = {6cc4b052e49dbc4f7463e8af2016b107}, intrahash = {3990e5a26ba71ebff4f6e7254fc6cbb0}, issn = {1364-548X}, journal = {Chemical communications (Cambridge, England)}, keywords = {bt3240 gene-expression}, month = dec, pmid = {23230569}, posted-at = {2013-03-06 09:49:12}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Artificial repressors for controlling gene expression in bacteria.}, url = {http://dx.doi.org/10.1039/c2cc37107c}, year = 2012 }