%0 Journal Article %1 wagner2017expression %A Wagner, Arnika K. %A Kadri, Nadir %A Snäll, Johanna %A Brodin, Petter %A Gilfillan, Susan %A Colonna, Marco %A Bernhardt, Günter %A Höglund, Petter %A Kärre, Klas %A Chambers, Benedict J. %D 2017 %J Nature Communications %K nk %N 1 %P 15627-- %R 10.1038/ncomms15627 %T Expression of CD226 is associated to but not required for NK cell education %U https://doi.org/10.1038/ncomms15627 %V 8 %X DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226−/− mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education.

@article{wagner2017expression, abstract = {DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226−/− mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education.}, added-at = {2020-04-02T17:09:08.000+0200}, author = {Wagner, Arnika K. and Kadri, Nadir and Snäll, Johanna and Brodin, Petter and Gilfillan, Susan and Colonna, Marco and Bernhardt, Günter and Höglund, Petter and Kärre, Klas and Chambers, Benedict J.}, biburl = {https://www.bibsonomy.org/bibtex/26d7e78eedcf5ff120efbaf1951bf1d34/lkanth}, description = {Expression of CD226 is associated to but not required for NK cell education | Nature Communications}, doi = {10.1038/ncomms15627}, interhash = {80e18cfec2a93bfc4e2086290b60f955}, intrahash = {6d7e78eedcf5ff120efbaf1951bf1d34}, issn = {20411723}, journal = {Nature Communications}, keywords = {nk}, number = 1, pages = {15627--}, refid = {Wagner2017}, timestamp = {2020-04-02T17:09:08.000+0200}, title = {Expression of CD226 is associated to but not required for NK cell education}, url = {https://doi.org/10.1038/ncomms15627}, volume = 8, year = 2017 }