%0 Journal Article %1 Iliev2000 %A Iliev, A. I. %A Traykov, V. B. %A Mantchev, G. T. %A Stoykov, I. %A Prodanov, D. %A Yakimova, K. S. %A Krushkov, I. M. %D 2000 %J J Pharm Pharmacol %K Animals Attack, Cholinesterase Galantamine/*therapeutic Inhibitors/*therapeutic Ischemic Learning/*drug Male Rats Sprague-Dawley Transient/*drug effects therapy use %N 9 %P 1151-6 %T A post-ischaemic single administration of galanthamine, a cholinesterase inhibitor, improves learning ability in rats %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11045897 %V 52 %X Transient forebrain ischaemia is widely observed in clinical practice. We have examined the effect of a single administration of the cholinesterase inhibitor galanthamine (2mg kg(-1) i.p.) 25 min after reperfusion in male Sprague-Dawley rats (180 +/- 20 g) after a 20-min common carotid artery occlusion. Twenty-four-hours post-ischaemia there was no difference in motor co-ordination or muscle tonus of the rats treated with or without galanthamine as assessed by the rota-rod test. Learning ability was examined using the shuttle-box test, evaluating the latency time and the number of errors for six days in succession. The performance of the ischaemic saline-injected rats was significantly impaired on days 4, 5, 6 (latency time) compared with the non-ischaemic rats and with the ischaemic animals administered galanthamine (P < 0.05). Similar results were obtained when counting the number of errors (failure to cross the cage during conditioned or unconditioned stimulus). The monitoring of body temperature during the first 12-h post-ischaemia did not show any significant difference between the groups. The data showed a beneficial effect of galanthamine on the recovery of learning ability when administered once only post-ischaemia. This suggests a direct effect on the early pathologic mechanisms of CNS damage. Cholinesterase inhibitors may prove useful in the early clinical treatment of ischaemic conditions.

@article{Iliev2000, abstract = {Transient forebrain ischaemia is widely observed in clinical practice. We have examined the effect of a single administration of the cholinesterase inhibitor galanthamine (2mg kg(-1) i.p.) 25 min after reperfusion in male Sprague-Dawley rats (180 +/- 20 g) after a 20-min common carotid artery occlusion. Twenty-four-hours post-ischaemia there was no difference in motor co-ordination or muscle tonus of the rats treated with or without galanthamine as assessed by the rota-rod test. Learning ability was examined using the shuttle-box test, evaluating the latency time and the number of errors for six days in succession. The performance of the ischaemic saline-injected rats was significantly impaired on days 4, 5, 6 (latency time) compared with the non-ischaemic rats and with the ischaemic animals administered galanthamine (P < 0.05). Similar results were obtained when counting the number of errors (failure to cross the cage during conditioned or unconditioned stimulus). The monitoring of body temperature during the first 12-h post-ischaemia did not show any significant difference between the groups. The data showed a beneficial effect of galanthamine on the recovery of learning ability when administered once only post-ischaemia. This suggests a direct effect on the early pathologic mechanisms of CNS damage. Cholinesterase inhibitors may prove useful in the early clinical treatment of ischaemic conditions.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Iliev, A. I. and Traykov, V. B. and Mantchev, G. T. and Stoykov, I. and Prodanov, D. and Yakimova, K. S. and Krushkov, I. M.}, biburl = {https://www.bibsonomy.org/bibtex/25b7a11839a77bd32bf54b0db9c797214/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {7387d2250146fe403288f76f499f92c3}, intrahash = {5b7a11839a77bd32bf54b0db9c797214}, issn = {0022-3573 (Print) 0022-3573 (Linking)}, journal = {J Pharm Pharmacol}, keywords = {Animals Attack, Cholinesterase Galantamine/*therapeutic Inhibitors/*therapeutic Ischemic Learning/*drug Male Rats Sprague-Dawley Transient/*drug effects therapy use}, month = Sep, note = {Iliev, A I Traykov, V B Mantchev, G T Stoykov, I Prodanov, D Yakimova, K S Krushkov, I M England The Journal of pharmacy and pharmacology J Pharm Pharmacol. 2000 Sep;52(9):1151-6.}, number = 9, pages = {1151-6}, shorttitle = {A post-ischaemic single administration of galanthamine, a cholinesterase inhibitor, improves learning ability in rats}, timestamp = {2010-12-14T18:22:56.000+0100}, title = {A post-ischaemic single administration of galanthamine, a cholinesterase inhibitor, improves learning ability in rats}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11045897}, volume = 52, year = 2000 }