%0 Journal Article %1 10.1371/journal.ppat.1006454 %A Zischke, J %A Mamareli, P %A Pokoyski, C %A Gabaev, I %A Buyny, S %A Jacobs, R %A Falk, C S %A Lochner, M %A Sparwasser, T %A Schulz, T F %A Kay-Fedorov, P C %D 2017 %E Pathog, PLoS %I Public Library of Science %J PLoS Pathog %K Sparwasser %N 6 %P 1-26 %T The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion %V 13 %X Author summary Human cytomegalovirus (HCMV) infects from 45% to 100% of people worldwide, depending on local socio-economic factors. Although usually harmless in healthy individuals, infection with HCMV can cause severe disease in people with weakened or immature immune systems such as transplant recipients and newborns. The establishment and maintenance of life-long infections by HCMV are greatly aided by its ability to modulate the host’s immune system during both active and latent infection; infected cells are masked and both infected and uninfected immune cells have their functions manipulated. One effect of HCMV infection is the induction of the cytokine IL-10, a secreted protein that suppresses many antiviral responses. Here, we identify a viral protein, pUL11, which can induce IL-10 expression by T cells and reduce the production of mediators of inflammation. pUL11 interacts with CD45, an immune system regulator that controls the sensitivity of T cells and has been linked to IL-10 production. We show that pUL11 can likewise affect T cell responses to stimuli, depending on its concentration, and suggest that this underlies its functions. pUL11 is the first viral protein known with this mechanism and further understanding of its effects may lead to the development of novel antiviral therapies and also help in the treatment of immune system disorders.

@article{10.1371/journal.ppat.1006454, abstract = {Author summary Human cytomegalovirus (HCMV) infects from 45% to 100% of people worldwide, depending on local socio-economic factors. Although usually harmless in healthy individuals, infection with HCMV can cause severe disease in people with weakened or immature immune systems such as transplant recipients and newborns. The establishment and maintenance of life-long infections by HCMV are greatly aided by its ability to modulate the host’s immune system during both active and latent infection; infected cells are masked and both infected and uninfected immune cells have their functions manipulated. One effect of HCMV infection is the induction of the cytokine IL-10, a secreted protein that suppresses many antiviral responses. Here, we identify a viral protein, pUL11, which can induce IL-10 expression by T cells and reduce the production of mediators of inflammation. pUL11 interacts with CD45, an immune system regulator that controls the sensitivity of T cells and has been linked to IL-10 production. We show that pUL11 can likewise affect T cell responses to stimuli, depending on its concentration, and suggest that this underlies its functions. pUL11 is the first viral protein known with this mechanism and further understanding of its effects may lead to the development of novel antiviral therapies and also help in the treatment of immune system disorders.}, added-at = {2017-08-09T12:33:53.000+0200}, author = {Zischke, J and Mamareli, P and Pokoyski, C and Gabaev, I and Buyny, S and Jacobs, R and Falk, C S and Lochner, M and Sparwasser, T and Schulz, T F and Kay-Fedorov, P C}, biburl = {https://www.bibsonomy.org/bibtex/2774f292bde3c835d8acd7b2aeb468f90/sparwasser}, editor = {Pathog, PLoS}, interhash = {73a728df1703ee46b31b66a32f8188e0}, intrahash = {774f292bde3c835d8acd7b2aeb468f90}, journal = {PLoS Pathog}, keywords = {Sparwasser}, month = {06}, number = 6, pages = {1-26}, publisher = {Public Library of Science}, pubmedurl = {https://www.ncbi.nlm.nih.gov/pubmed/28628650}, timestamp = {2017-08-09T12:33:53.000+0200}, title = {The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion}, volume = 13, year = 2017 }