%0 Generic %1 nyholt2004simple %A Nyholt, Dale R. %D 2004 %I University of Chicago Press %J American journal of human genetics %K SNP linkage population_genomics statistics %N 4 %P 765--769 %T A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other %U http://linkinghub.elsevier.com/retrieve/pii/S000292970761903X %V 74 %X In this report, we describe a simple correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of pairwise LD between SNPs. This method provides a useful alternative to more computationally intensive permutation tests. A user-friendly interface (SNPSpD) for performing this correction is available online (http://genepi.qimr.edu.au/general/daleN/SNPSpD/). Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor loadings after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region.

@misc{nyholt2004simple, abstract = {In this report, we describe a simple correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of pairwise LD between SNPs. This method provides a useful alternative to more computationally intensive permutation tests. A user-friendly interface (SNPSpD) for performing this correction is available online (http://genepi.qimr.edu.au/general/daleN/SNPSpD/). Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor loadings after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region.}, added-at = {2012-09-08T22:24:55.000+0200}, author = {Nyholt, Dale R.}, biburl = {https://www.bibsonomy.org/bibtex/27548f945ad484a879e2d1b6dbedd3f4e/peter.ralph}, interhash = {76fe6441365e1c48d71b6786aeb2b0bc}, intrahash = {7548f945ad484a879e2d1b6dbedd3f4e}, issn = {00029297}, journal = {American journal of human genetics}, keywords = {SNP linkage population_genomics statistics}, month = apr, number = 4, pages = {765--769}, publisher = {University of Chicago Press}, refid = {S0002-9297(07)61903-X DOI - 10.1086/383251}, timestamp = {2012-09-08T22:24:56.000+0200}, title = {A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other}, url = {http://linkinghub.elsevier.com/retrieve/pii/S000292970761903X}, volume = 74, year = 2004 }