Abstract
PURPOSE: This paper reviews 10 principles of experience-dependent
neural plasticity and considerations in applying them to the damaged
brain. METHOD: Neuroscience research using a variety of models of
learning, neurological disease, and trauma are reviewed from the
perspective of basic neuroscientists but in a manner intended to
be useful for the development of more effective clinical rehabilitation
interventions. RESULTS: Neural plasticity is believed to be the basis
for both learning in the intact brain and relearning in the damaged
brain that occurs through physical rehabilitation. Neuroscience research
has made significant advances in understanding experience-dependent
neural plasticity, and these findings are beginning to be integrated
with research on the degenerative and regenerative effects of brain
damage. The qualities and constraints of experience-dependent neural
plasticity are likely to be of major relevance to rehabilitation
efforts in humans with brain damage. However, some research topics
need much more attention in order to enhance the translation of this
area of neuroscience to clinical research and practice. CONCLUSION:
The growing understanding of the nature of brain plasticity raises
optimism that this knowledge can be capitalized upon to improve rehabilitation
efforts and to optimize functional outcome.
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