%0 Journal Article %1 RN185 %A Salgado, F. %A Areche, C. %A Sepulveda, B. %A Simirgiotis, M.J. %A Caceres, F. %A Quispe, C. %A Quispe, L. %A Cano, T. %D 2014 %J Pharmacognosy Magazine %K acaulis, acids activity, apiaceae, azorella carbon compacta, crassifolium, diterpenoids, dqcauchile gastroprotective madreporica, mulinanes, natural-products, skeleton, umbelliferae, %N 39 %P 543-548 %R 10.4103/0973-1296.139807 %T A New Mulinane Diterpenoid from the Cushion Shrub Azorella Compacta Growing in Peru %U /brokenurl#<Go to ISI>://WOS:000341875000014 %V 10 %X Background: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Per to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric-induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1-6) present in the dichloromethane (DCM) extract of A. compacta growing in Per were isolated by a combination of Sephadex LH-20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH-induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Per showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH-induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2-6) showing an oxygenated function at C-16 or/and C-20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.

@article{RN185, abstract = {Background: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Per to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric-induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1-6) present in the dichloromethane (DCM) extract of A. compacta growing in Per were isolated by a combination of Sephadex LH-20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH-induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Per showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH-induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2-6) showing an oxygenated function at C-16 or/and C-20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.}, added-at = {2019-12-04T03:57:35.000+0100}, author = {Salgado, F. and Areche, C. and Sepulveda, B. and Simirgiotis, M.J. and Caceres, F. and Quispe, C. and Quispe, L. and Cano, T.}, biburl = {https://www.bibsonomy.org/bibtex/2401f5a866baeb1eae6f70549305dc1b1/dqcauchile}, doi = {10.4103/0973-1296.139807}, interhash = {7f25b7c5f1e0c3717e36e22e7a285d37}, intrahash = {401f5a866baeb1eae6f70549305dc1b1}, issn = {0973-1296}, journal = {Pharmacognosy Magazine}, keywords = {acaulis, acids activity, apiaceae, azorella carbon compacta, crassifolium, diterpenoids, dqcauchile gastroprotective madreporica, mulinanes, natural-products, skeleton, umbelliferae,}, number = 39, pages = {543-548}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {A New Mulinane Diterpenoid from the Cushion Shrub Azorella Compacta Growing in Peru}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000341875000014}, volume = 10, year = 2014 }