Abstract
A facile procedure is developed for the three-component Mannich
reactions of several heterocyclic, homocyclic, and acyclic ketones by
using catalytic quantities of nano ZrO2. As a result, the starting
ketones undergo rapid reactions with a variety of aromatic aldehydes and
aniline derivatives at room temperature to produce stereoselectively
high yields of the corresponding anti beta-amino ketones. Interestingly,
the catalyst could be recycled for several runs in a row without
significant loss of its activity. The structure of the products was
assigned based on their spectroscopic data and the anti
stereoselectivity was confirmed by X-ray crystallography.
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