Abstract
The basic goal of small-molecule screening is the identification of
chemically 'interesting' starting points for elaboration towards
a drug. A number of innovative approaches for pursuing this goal
have evolved, and the right approach is dictated by the target class
being pursued and the capabilities of the organization involved.
A recent trend in high-throughput screening has been to place less
emphasis on the number of data points that can be produced, and to
focus instead on the quality of the data obtained. Several computational
and technological advances have aided in the selection of compounds
for screening and widened the variety of assay formats available
for screening. The effect on the efficiency of the screening process
is discussed.
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