Article,
Gene therapy approaches for modulating bone regeneration.
Adv Drug Deliv Rev, 42 (1-2): 121-38 (2000)
Abstract
Following injury, bone has the ability to regenerate itself to a form
and function nearly indistinguishable from the pre-injury state.
However, if the injury is beyond a critical limit, recovery will
not occur without therapeutic interventions. Autografts and implants
with banked bone continue as the treatments of choice, although each
exhibits limitations and liabilities. Alternatives have included
the utilization of bone-graft substitutes that may incorporate bone
derivatives and soluble signaling molecules such as mitogens and
morphogens. In addition, an evolving treatment modality, gene therapy,
offers an exciting avenue for bone regeneration. This review presents
some of the current concepts for developing a rational gene therapy
approach in bone regeneration.
Tags
- *bone
- *gene
- ;
- animals
- bone
- bone/therapy
- cytokines/therapeutic
- fractures,
- gene
- genetic
- humans
- morphogenetic
- proteins/therapeutic
- regeneration
- targeting
- therapy
- use
- vectors
