Аннотация
Obtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a
range of important pharmacological properties. FTL activates and
modulates lymphocytes and neutrophils and possesses gastroprotective
effects. The purpose of this study was to evaluate the ability of FTL to
protect the gastric mucosa of mice submitted to ethanol-induced gastric
injury. The gastroprotective effect of frutalina was evaluated using a
murine model of ethanol-induced gastric injury. Damage of the gastric
mucosa was assessed morphologically by light, scanning electron and
atomic force microscopy. Lymphocyte infiltration, necrosis, disruption
of the mucosal structures and epithelial desquamation were observed in
the control group. In the group pretreated with frutalina at 0.5 mg/kg,
gastroprotection, reduced tissue damage and preserved submucosal and
mucosal structures were observed. In conclusion, FTL displayed
gastroprotective activity against ethanol-induced gastric injury,
preventing the formation of gastric ulcer and reducing epithelial
desquamation, glandular damage, mucosal necrosis and infiltration. The
observed effects appear to be due to mechanisms previously described for
frutalin.
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