%0 Journal Article %1 carolina_telini_rosa_rodrigues_alves_2021_5205462 %A Alves, Carolina Telini Rosa Rodrigues %A Junqueira, Eduardo Monteiro Diniz %A de Lellis Sandoval Filho, Camillo %A Antonio, Juliana Cruzera %A Iyomasa-Pilon, Melina Mizusaki %A Souza, Helena Ribeiro %A Girol, Ana Paula %D 2021 %J World Journal of Biology Pharmacy and Health Sciences %K Wound healing %N 2 %P 032-042 %R 10.30574/wjbphs.2021.7.2.0077 %T Cutaneous wound healing modulation of lesions infected by Staphylococcus epidermidis and treated with 4% stabilized sodium hypochlorite solution %U https://wjbphs.com/content/cutaneous-wound-healing-modulation-lesions-infected-staphylococcus-epidermidis-and-treated-4 %V 7 %X Background: Stabilized sodium hypochlorite solution at 4% (4% NaClO) is a product with healing properties but still little studied scientifically. Here we evaluated the administration of 4% NaClO in a model of clean and infected skin lesions. Methods: Lesions were obtained on the dorsal region of Wistar rats. The wounds of some animals were inoculated with Staphylococcus epidermidis (50uL, 10-7) and clean and infected lesions were treated with Trofodermin® or 4% NaClO (diluted at 0.4%) as the following groups: Trofodermin®; S. epidermidis + Trofodermin®; 4% NaClO; S. epidermidis + 4% NaClO. Wounds sizes were daily measured and the excision of lesions was performed on day 8 for histopathological evaluation and immunohistochemical studies of Annexin A1 (AnxA1), receptors for formylated peptides (FPR)1 and FPR2 and vascular endothelial growth factor (VEGF). Levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the supernatants of the macerated lesions were also measured. Results: Wounds treated with 4% NaClO closed faster than those treated with Trofodermin®, especially in the infected group. 4% NaClO reduced the expressions of AnxA1, FPR1, FPR2 and VEGF, as well as decreased the levels of IL-1β. Conclusion: These results pointed the potential of 4% NaClO in wound healing which opens the possibility for new therapeutic strategies.

@article{carolina_telini_rosa_rodrigues_alves_2021_5205462, abstract = {Background: Stabilized sodium hypochlorite solution at 4% (4% NaClO) is a product with healing properties but still little studied scientifically. Here we evaluated the administration of 4% NaClO in a model of clean and infected skin lesions. Methods: Lesions were obtained on the dorsal region of Wistar rats. The wounds of some animals were inoculated with Staphylococcus epidermidis (50uL, 10-7) and clean and infected lesions were treated with Trofodermin® or 4% NaClO (diluted at 0.4%) as the following groups: Trofodermin®; S. epidermidis + Trofodermin®; 4% NaClO; S. epidermidis + 4% NaClO. Wounds sizes were daily measured and the excision of lesions was performed on day 8 for histopathological evaluation and immunohistochemical studies of Annexin A1 (AnxA1), receptors for formylated peptides (FPR)1 and FPR2 and vascular endothelial growth factor (VEGF). Levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the supernatants of the macerated lesions were also measured. Results: Wounds treated with 4% NaClO closed faster than those treated with Trofodermin®, especially in the infected group. 4% NaClO reduced the expressions of AnxA1, FPR1, FPR2 and VEGF, as well as decreased the levels of IL-1β. Conclusion: These results pointed the potential of 4% NaClO in wound healing which opens the possibility for new therapeutic strategies.}, added-at = {2021-08-16T10:48:27.000+0200}, author = {Alves, Carolina Telini Rosa Rodrigues and Junqueira, Eduardo Monteiro Diniz and de Lellis Sandoval Filho, Camillo and Antonio, Juliana Cruzera and Iyomasa-Pilon, Melina Mizusaki and Souza, Helena Ribeiro and Girol, Ana Paula}, biburl = {https://www.bibsonomy.org/bibtex/25ec5b1f4a88d05c636f638cc0dfdf3e4/wjbphsjournal}, doi = {10.30574/wjbphs.2021.7.2.0077}, interhash = {90d438238acbb575dfe8378cfc2a06eb}, intrahash = {5ec5b1f4a88d05c636f638cc0dfdf3e4}, issn = {2582-5542}, journal = {{World Journal of Biology Pharmacy and Health Sciences}}, keywords = {Wound healing}, month = aug, number = 2, pages = {032-042}, timestamp = {2021-08-16T10:48:27.000+0200}, title = {Cutaneous wound healing modulation of lesions infected by Staphylococcus epidermidis and treated with 4% stabilized sodium hypochlorite solution}, url = {https://wjbphs.com/content/cutaneous-wound-healing-modulation-lesions-infected-staphylococcus-epidermidis-and-treated-4}, volume = 7, year = 2021 }