%0 Journal Article %1 Bito_2008_315 %A Bito, Virginie %A Heinzel, Frank R %A Biesmans, Liesbeth %A Antoons, Gudrun %A Sipido, Karin R %D 2008 %J Cardiovasc Res %K Animals; Arrhythmias, Biochemical; Calcium Calcium, Cardiac, Cardiomegaly, Channel, Channels, Contraction; Failure, Feedback, Heart Humans; L-Type, Myocardial Rate; Receptor Release Reticulum, Ryanodine Sarcoplasmic etiology; metabolism; physiology physiology; %N 2 %P 315--324 %R 10.1093/cvr/cvm063 %T Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling. %U http://dx.doi.org/10.1093/cvr/cvm063 %V 77 %X In the cardiac dyad, sarcolemmal L-type Ca(2+) channels (LCCs) and sarcoplasmic reticulum (SR) Ca(2+) release channels (RyR) are structurally in close proximity. This organization provides for an efficient functional coupling, tuning SR Ca(2+) release for optimal contraction of the myocyte. Given that LCC are regulated by the prevailing Ca(2+), this structural organization is the setting for feedback mechanisms and crosstalk. A defective coupling of Ca(2+) influx via LCC to activation of RyR has been implicated in reduced SR Ca(2+) release in heart failure. Both functional changes in LCC properties and structural re-organization of LCC in T-tubules could be involved. LCC are regulated by cytosolic Ca(2+), and crosstalk with SR Ca(2+) handling occurs on a long-term basis, i.e. during steady-state changes in heart rate, on an intermediate-term basis, i.e. on a beat-to-beat basis during sudden rate changes, and on a very short- or immediate-term basis, i.e. during a single heartbeat. We review the properties and consequences of these different feedback mechanisms and the changes in heart failure and cardiac hypertrophy that have thus far been studied.

@article{Bito_2008_315, abstract = {In the cardiac dyad, sarcolemmal L-type Ca(2+) channels (LCCs) and sarcoplasmic reticulum (SR) Ca(2+) release channels (RyR) are structurally in close proximity. This organization provides for an efficient functional coupling, tuning SR Ca(2+) release for optimal contraction of the myocyte. Given that LCC are regulated by the prevailing [Ca(2+)], this structural organization is the setting for feedback mechanisms and crosstalk. A defective coupling of Ca(2+) influx via LCC to activation of RyR has been implicated in reduced SR Ca(2+) release in heart failure. Both functional changes in LCC properties and structural re-organization of LCC in T-tubules could be involved. LCC are regulated by cytosolic Ca(2+), and crosstalk with SR Ca(2+) handling occurs on a long-term basis, i.e. during steady-state changes in heart rate, on an intermediate-term basis, i.e. on a beat-to-beat basis during sudden rate changes, and on a very short- or immediate-term basis, i.e. during a single heartbeat. We review the properties and consequences of these different feedback mechanisms and the changes in heart failure and cardiac hypertrophy that have thus far been studied.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Bito, Virginie and Heinzel, Frank R and Biesmans, Liesbeth and Antoons, Gudrun and Sipido, Karin R}, biburl = {https://www.bibsonomy.org/bibtex/2cf78668889e19753281a6fb14d85492d/hake}, description = {The whole bibliography file I use.}, doi = {10.1093/cvr/cvm063}, file = {Bito_2008_315.pdf:Bito_2008_315.pdf:PDF}, institution = {Department of Cardiovascular Medicine, Division of Experimental Cardiology, University of Leuven, KUL Campus Gasthuisberg O/N 7th floor, Herestraat 49, B-3000 Leuven, Belgium.}, interhash = {90e186956f7bcea968784fa97b0f6ced}, intrahash = {cf78668889e19753281a6fb14d85492d}, journal = {Cardiovasc Res}, keywords = {Animals; Arrhythmias, Biochemical; Calcium Calcium, Cardiac, Cardiomegaly, Channel, Channels, Contraction; Failure, Feedback, Heart Humans; L-Type, Myocardial Rate; Receptor Release Reticulum, Ryanodine Sarcoplasmic etiology; metabolism; physiology physiology;}, month = Jan, number = 2, pages = {315--324}, pdf = {Bito_2008_315.pdf}, pii = {cvm063}, pmid = {18006436}, timestamp = {2009-06-03T11:21:03.000+0200}, title = {Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling.}, url = {http://dx.doi.org/10.1093/cvr/cvm063}, volume = 77, year = 2008 }