Abstract
Many tumor types including that of the ovary show loss of heterozygosity
(LOH) on chromosome arm 7q, which suggests the existence of at least
one tumor suppressor gene (TSG) on this chromosome arm. We have studied
the region surrounding the putative tumor suppressor gene CUTL1 at
7q22 in 127 epithelial ovarian tumors. LOH was found across 7q22
in 31% of malignant and 14% of benign ovarian tumors. In 16% of the
tumors the LOH appeared to be centered on the CUTL1 gene. This gene
has been implicated previously as a TSG in both uterine leiomyomas
and breast carcinoma. However, mutation analysis of the CUTL1 gene
in 47 tumors with 7q22 LOH failed to identify any somatic alterations
in the coding regions. This finding suggests that CUTL1 may not be
the target of the 7q22 LOH in ovarian cancers.
- adenocarcinoma,_mucinous,_genetics
- carcinoma,_endometrioid,_genetics
- chromosomes,_human,_pair_7,_genetics
- cystadenocarcinoma,_serous,_genetics
- dna_mutational_analysis
- dna_primers,_genetics
- female
- genes,_tumor_suppressor,_genetics
- homeodomain_proteins
- humans
- loss_of_heterozygosity
- microsatellite_repeats,_genetics
- neoplasm_proteins,_genetics
- nuclear_proteins,_genetics
- ovarian_neoplasms,_genetics
- repressor_proteins,_genetics
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