Аннотация
Computational models of the electrical and mechanical function of
the heart are reviewed. These models attempt to explain the integrated
function of the heart in terms of ventricular anatomy, the structure
and material properties of myocardial tissue, the membrane ion channels,
and calcium handling and myofilament mechanics of cardiac myocytes.
The models have established the computational framework for linking
the structure and function of cardiac cells and tissue to the integrated
behavior of the intact heart, but many more aspects of physiological
function, including metabolic and signal transduction pathways, need
to be included before significant progress can be made in understanding
many disease processes.
- 14527312
- animals,
- blood
- cardiac,
- cardiovascular,
- circulation,
- conduction
- contraction,
- coronary
- flow
- function,
- heart
- heart,
- hemorheology,
- humans,
- mechanical,
- models,
- myocardial
- myocytes,
- stress,
- system,
- velocity,
- ventricular
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