Article,
Gene networks: Meaningful connections
Nature Reviews Genetics, (Feb 9, 2010)
DOI: 10.1038/nrg2756
Abstract
The magnitude and direction of epistasis and the functional consequences of these gene–gene interactions are fundamental to relating genotype to phenotype and thus for informing fields from human disease to speciation. The detailed analysis of global metabolic and genetic interactions in Escherichia coli and Saccharomyces cerevisiae highlights the potential of such surveys for functionally annotating the genome, and also overturns some widely held assumptions.
