%0 Journal Article %1 Garland2002 %A Garland, Suzanne M %A Chuileann?in, Fiona N? %A Satzke, Catherine %A Robins-Browne, Roy %D 2002 %J J Reprod Immunol %K Biological Markers; Cerebral Palsy; Female; Humans; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Streptococcal Infections; Streptococcus agalactiae; Trichomonas Vaginitis; Vaginosis, Bacterial %N 1-2 %P 169--183 %T Mechanisms, organisms and markers of infection in pregnancy. %V 57 %X Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50\% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.

@article{Garland2002, abstract = {Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50\% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.}, added-at = {2014-07-19T19:31:20.000+0200}, author = {Garland, Suzanne M and Chuileann?in, Fiona N? and Satzke, Catherine and Robins-Browne, Roy}, biburl = {https://www.bibsonomy.org/bibtex/2b44b575191ff2fb747d956cf41ad4f42/ar0berts}, groups = {public}, interhash = {9923032ff3e437f14724c60069d26b6b}, intrahash = {b44b575191ff2fb747d956cf41ad4f42}, journal = {J Reprod Immunol}, keywords = {Biological Markers; Cerebral Palsy; Female; Humans; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Streptococcal Infections; Streptococcus agalactiae; Trichomonas Vaginitis; Vaginosis, Bacterial}, number = {1-2}, pages = {169--183}, pii = {S0165037802000189}, pmid = {12385841}, timestamp = {2014-07-19T19:31:20.000+0200}, title = {Mechanisms, organisms and markers of infection in pregnancy.}, username = {ar0berts}, volume = 57, year = 2002 }