Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized
by motor, cognitive, neuropsychiatric, autonomic, and other nonmotor
symptoms. The efficacy of deep brain stimulation (DBS) for the motor
symptoms of advanced PD is well established. However, the effects
of DBS on the cognitive and neuropsychiatric symptoms are less clear.
The neuropsychiatric aspects of DBS for PD have recently been of
considerable clinical and pathophysiological interest. As a companion
to the preoperative and postoperative sections of the DBS consensus
articles, this article reviews the published literature on the cognitive
and neuropsychiatric aspects of DBS for PD. The majority of the observed
neuropsychiatric symptoms are transient, treatable, and potentially
preventable. Outcome studies, methodological issues, pathophysiology,
and preoperative and postoperative management of the cognitive and
neuropsychiatric aspects and complications of DBS for PD are discussed.
- brain
- cognition
- complications,parkinson
- complications,subthalamic
- diagnosis,cognition
- diagnosis,depression:
- diagnosis,hallucinations:
- disease,parkinson
- disease:
- disorders,cognition
- disorders:
- etiology,deep
- etiology,depression:
- etiology,hallucinations:
- instrumentation,depression,depression:
- nucleus,subthalamic
- nucleus:
- physiology
- physiology,thalamus,thalamus:
- stimulation,deep
- stimulation:
- tests,parkinson
- therapy,hallucinations,hallucinations:
- therapy,humans,neuropsychological
- therapy,postoperative
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