%0 Journal Article %1 Thorarensen1997 %A Thorarensen, O. %A Ryan, S. %A Hunter, J. %A Younkin, D. P. %D 1997 %J Ann Neurol %K Brain Ischemia; Cerebral Palsy; Cerebrovascular Disorders; Factor V; Female; Hemiplegia; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male; Placenta; Point Mutation; Pregnancy; Protein C; Thrombosis %N 3 %P 372--375 %R 10.1002/ana.410420316 %T Factor V Leiden mutation: an unrecognized cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis. %U http://dx.doi.org/10.1002/ana.410420316 %V 42 %X Activated protein C resistance caused by an Arg506Gln mutation in the factor V gene (factor V Leiden mutation) is the most common cause of familial thrombosis. This mutation is associated with arterial and venous thromboembolic disease in neonates, infants, and children, but is not a significant risk factor for ischemic stroke in adults. We report on 3 babies with different neonatal cerebrovascular disorders including ischemic infarction and hemorrhagic stroke who are heterozygous for factor V Leiden mutation. One infant had multiple thrombi in the fetal placental vasculature. This is the first reported association between hemiplegic cerebral palsy, placental thrombosis, and factor V Leiden mutation. We suspect that activated protein C resistance may be an important cause of in utero cerebrovascular disease and hemiplegic cerebral palsy.

@article{Thorarensen1997, abstract = {Activated protein C resistance caused by an Arg506Gln mutation in the factor V gene (factor V Leiden mutation) is the most common cause of familial thrombosis. This mutation is associated with arterial and venous thromboembolic disease in neonates, infants, and children, but is not a significant risk factor for ischemic stroke in adults. We report on 3 babies with different neonatal cerebrovascular disorders including ischemic infarction and hemorrhagic stroke who are heterozygous for factor V Leiden mutation. One infant had multiple thrombi in the fetal placental vasculature. This is the first reported association between hemiplegic cerebral palsy, placental thrombosis, and factor V Leiden mutation. We suspect that activated protein C resistance may be an important cause of in utero cerebrovascular disease and hemiplegic cerebral palsy.}, added-at = {2014-07-19T21:43:14.000+0200}, author = {Thorarensen, O. and Ryan, S. and Hunter, J. and Younkin, D. P.}, biburl = {https://www.bibsonomy.org/bibtex/2f13d60c670f62348a443a990d1e1d34c/ar0berts}, doi = {10.1002/ana.410420316}, groups = {public}, interhash = {9d6172cf24413e02c5d1efaf6f850a5d}, intrahash = {f13d60c670f62348a443a990d1e1d34c}, journal = {Ann Neurol}, keywords = {Brain Ischemia; Cerebral Palsy; Cerebrovascular Disorders; Factor V; Female; Hemiplegia; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male; Placenta; Point Mutation; Pregnancy; Protein C; Thrombosis}, month = Sep, number = 3, pages = {372--375}, pmid = {9307261}, timestamp = {2014-07-19T21:48:34.000+0200}, title = {Factor V Leiden mutation: an unrecognized cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis.}, url = {http://dx.doi.org/10.1002/ana.410420316}, username = {ar0berts}, volume = 42, year = 1997 }