%0 Journal Article %1 fuchs_proteome_2007 %A Fuchs, Dagmar %A Dirscherl, Barbara %A Schroot, Joyce H %A Daniel, Hannelore %A Wenzel, Uwe %D 2007 %J Journal of proteome research %K Apoptosis Endothelial_Cells Endothelium Genistein Humans IFZ Isoflavones LDL Lipoproteins Mass Matrix-Assisted_Laser_Desorption-Ionization Mitochondria Oxidation-Reduction Plant_Extracts Proteome Soybeans Spectrometry Vascular %P 2132-42 %T Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones %V 6 %X Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.

@article{fuchs_proteome_2007, abstract = {Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.}, added-at = {2008-07-17T15:18:16.000+0200}, author = {Fuchs, Dagmar and Dirscherl, Barbara and Schroot, Joyce H and Daniel, Hannelore and Wenzel, Uwe}, biburl = {https://www.bibsonomy.org/bibtex/2eecdfce895746a0e03e751a0d961a54d/molnutrition}, interhash = {9ed155c45a4de82df0996b6fbb1d7082}, intrahash = {eecdfce895746a0e03e751a0d961a54d}, issn = {15353893}, journal = {Journal of proteome research}, keywords = {Apoptosis Endothelial_Cells Endothelium Genistein Humans IFZ Isoflavones LDL Lipoproteins Mass Matrix-Assisted_Laser_Desorption-Ionization Mitochondria Oxidation-Reduction Plant_Extracts Proteome Soybeans Spectrometry Vascular}, pages = {2132-42}, timestamp = {2008-07-18T14:02:30.000+0200}, title = {Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones}, volume = 6, year = 2007 }