Abstract
Many polymorphisms have been described for the genes encoding the
beta 1, beta 2, and alpha 2c-adrenoceptors that result in altered
signaling and/or regulatory properties of the receptors. Several
studies have investigated whether these properties affect the cardiovascular
function of these receptors in mice or in humans, but have yielded
mixed results. Some studies suggest that adrenoceptor polymorphisms
might alter the risk for heart failure and the response to treatment
with beta-blockers. However, the complex haplotypes resulting from
combinations of individual polymorphisms have not yet been investigated,
and firm conclusions or recommendations cannot be made because of
the low patient numbers in each of the study programs.
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