%0 Journal Article %1 Wu2008Integrated %A Wu, Jianmin %A Vallenius, Tea %A Ovaska, Kristian %A Westermarck, Jukka %A Makela, Tomi P. %A Hautaniemi, Sampsa %D 2008 %I Nature Publishing Group %J Nature Methods %K networks protein-protein-interactions software %N 1 %P 75--77 %R 10.1038/nmeth.1282 %T Integrated network analysis platform for protein-protein interactions %U http://dx.doi.org/10.1038/nmeth.1282 %V 6 %X There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFβ signaling, and revealed possible competitive interactors of p53 and c-Jun.

@article{Wu2008Integrated, abstract = {There is an increasing demand for network analysis of protein-protein interactions ({PPIs}). We introduce a web-based protein interaction network analysis platform ({PINA}), which integrates {PPI} data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of {PINA} by analyzing two human {PPI} networks; our results suggested a link between {LKB1} and {TGFβ} signaling, and revealed possible competitive interactors of p53 and {c-Jun}.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Wu, Jianmin and Vallenius, Tea and Ovaska, Kristian and Westermarck, Jukka and Makela, Tomi P. and Hautaniemi, Sampsa}, biburl = {https://www.bibsonomy.org/bibtex/245c957f32990eaaa3d337cd624dc9f3c/karthikraman}, citeulike-article-id = {3805274}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nmeth.1282}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nmeth.1282}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19079255}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19079255}, day = 14, doi = {10.1038/nmeth.1282}, interhash = {9f91b63b62fd5c696654cc01f53ac463}, intrahash = {45c957f32990eaaa3d337cd624dc9f3c}, issn = {1548-7091}, journal = {Nature Methods}, keywords = {networks protein-protein-interactions software}, month = dec, number = 1, pages = {75--77}, pmid = {19079255}, posted-at = {2009-11-27 08:50:49}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Integrated network analysis platform for protein-protein interactions}, url = {http://dx.doi.org/10.1038/nmeth.1282}, volume = 6, year = 2008 }