%0 Journal Article %1 hong2008dorsal %A Hong, J W %A Hendrix, D A %A Papatsenko, D %A Levine, M S %D 2008 %J Proc Natl Acad Sci U S A %K dorsal-ventral stochastic_transcription %N 51 %P 20072-20076 %R 10.1073/pnas.0806476105 %T How the Dorsal gradient works: insights from postgenome technologies %U http://www.ncbi.nlm.nih.gov/pubmed/19104040 %V 105 %X Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.

@article{hong2008dorsal, abstract = {Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.}, added-at = {2010-05-06T21:41:23.000+0200}, author = {Hong, J W and Hendrix, D A and Papatsenko, D and Levine, M S}, biburl = {https://www.bibsonomy.org/bibtex/24886c2a592c431616e976566dbed474d/peter.ralph}, description = {How the Dorsal gradient works: insights from postg... [Proc Natl Acad Sci U S A. 2008] - PubMed result}, doi = {10.1073/pnas.0806476105}, interhash = {a40152393ecdd1ddf93ecba2c3c39c11}, intrahash = {4886c2a592c431616e976566dbed474d}, journal = {Proc Natl Acad Sci U S A}, keywords = {dorsal-ventral stochastic_transcription}, month = dec, number = 51, pages = {20072-20076}, pmid = {19104040}, timestamp = {2010-05-06T21:41:23.000+0200}, title = {How the {Dorsal} gradient works: insights from postgenome technologies}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19104040}, volume = 105, year = 2008 }