%0 Journal Article %1 citeulike:7801915 %A Calderon, Andres J. %A Eshpuniyani, Brijesh %A Fowlkes, J. Brian %A Bull, Joseph L. %D 2010 %J Physics of Fluids %K microhydraulics 76t10-liquid-gas-two-phase-flows-bubbly-flows 76m15-boundary-element-methods-in-fluid-mechanics %N 6 %P 061902+ %T A Boundary Element Model of the Transport of a Semi-Infinite Bubble through a Microvessel Bifurcation %V 22 %X Motivated by a developmental gas embolotherapy technique for selective occlusion of blood flow to tumors, we examined the transport of a pressure-driven semi-infinite bubble through a liquid-filled bifurcating channel. Homogeneity of bubble splitting as the bubble passes through a vessel bifurcation affects the degree to which the vascular network near the tumor can be uniformly occluded. The homogeneity of bubble splitting was found to increase with bubble driving pressure and to decrease with increased bifurcation angle. Viscous losses at the bifurcation were observed to affect the bubble speed significantly. The potential for oscillating bubble interfaces to induce flow recirculation and impart high stresses on the vessel endothelium was also observed.

@article{citeulike:7801915, abstract = {{Motivated by a developmental gas embolotherapy technique for selective occlusion of blood flow to tumors, we examined the transport of a pressure-driven semi-infinite bubble through a liquid-filled bifurcating channel. Homogeneity of bubble splitting as the bubble passes through a vessel bifurcation affects the degree to which the vascular network near the tumor can be uniformly occluded. The homogeneity of bubble splitting was found to increase with bubble driving pressure and to decrease with increased bifurcation angle. Viscous losses at the bifurcation were observed to affect the bubble speed significantly. The potential for oscillating bubble interfaces to induce flow recirculation and impart high stresses on the vessel endothelium was also observed.}}, added-at = {2017-06-29T07:13:07.000+0200}, author = {Calderon, Andres J. and Eshpuniyani, Brijesh and Fowlkes, J. Brian and Bull, Joseph L.}, biburl = {https://www.bibsonomy.org/bibtex/2cdd7d9fc7ea3536e9bfc72e32c3e7868/gdmcbain}, citeulike-article-id = {7801915}, citeulike-attachment-1 = {calderon_et_al_physics_fluids_2010.pdf; /pdf/user/gdmcbain/article/7801915/540819/calderon_et_al_physics_fluids_2010.pdf; 10f69d9685e86bdf494dfe9c2d7226a8031326c9}, comment = {(private-note)circulated by SGM 2010-09-09}, file = {calderon_et_al_physics_fluids_2010.pdf}, interhash = {a61eb5c472989894911562a030de067e}, intrahash = {cdd7d9fc7ea3536e9bfc72e32c3e7868}, journal = {Physics of Fluids}, keywords = {microhydraulics 76t10-liquid-gas-two-phase-flows-bubbly-flows 76m15-boundary-element-methods-in-fluid-mechanics}, number = 6, pages = {061902+}, posted-at = {2010-09-09 06:29:52}, priority = {2}, timestamp = {2019-04-02T01:46:07.000+0200}, title = {{A Boundary Element Model of the Transport of a Semi-Infinite Bubble through a Microvessel Bifurcation}}, volume = 22, year = 2010 }