Abstract
BACKGROUND: Examination of the influence of dorzolamide on the autoregulation of
retinal vessel diameter in glaucoma patients. PATIENTS AND METHODS: Eleven
patients with primary open angle glaucoma (age 60 +/- 11) without medication and
four weeks after starting therapy with dorzolamid eye drops three times daily
were examined in the study. Short-time rise of intraocular pressure (IOP) was
obtained via suction-cup. Functional reaction of the diameter of a segment of a
retinal artery and corresponding vein were assessed by retinal vessel analyzer.
RESULTS: Dorzolamid lowered the IOP from 23.3 +/- 1.3 to 17.6 +/- 2.2 mmHg (p =
0.004). Therapy did not influence the absolute diameter of retinal vessels
regarding maximal dilatation caused by the pressure rising provocation. In eyes
with treatment the diameter decreased faster to baseline values (arteries 100
sec, veins 220 sec) compared to those without treatment (arteries 350 sec, veins
480 sec). CONCLUSION: Dorzolamid might possibly be able to accelerate
autoregulation of retinal vessels in response to short term artificial IOP
increase.
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